SynthesisFrontiers in toxicology2025
Systematic literature review and meta-analysis on the reproductive effects of micro- pollutants in humans and animals.
Synthesis in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Trace Element Dyshomeostasis as a Mediator of Toxic Metal-Induced Reproductive Dysfunction: Mechanistic Insights and Future Perspectives.Biological trace element research · 2026Review
- Comprehensive Insight into the Male Dog Reproductive System in Health and Diseases: Developmental, Genetic, and Environmental Factors-Review on Research and Clinical Trials.Veterinary sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Micro-pollutants, such as particulate matter, heavy metals, endocrine-disrupting compounds, and persistent organic pollutants, raise significant concerns regarding reproductive health in both humans and animals. Methods: This systematic review and meta-analysis, conducted according to PRISMA guidelines, assessed available evidence on micro-pollutant exposure and reproductive outcomes. Out of 2,134 records identified, 52 studies (31 human, 21 animal) met inclusion criteria. Results: Exposure to micro-pollutants was consistently associated with adverse reproductive outcomes. Human studies reported increased risks of irregular menstruation, preterm delivery (OR = 1.42), intrauterine growth restriction (OR = 1.36), and reductions in sperm concentration (SMD = -0.48) and testosterone levels. A meta-analysis of 23 studies confirmed these associations, while animal studies provided mechanistic support, including histological damage and epigenetic modifications. Despite substantial heterogeneity, the overall quality of included studies was moderate-to-high. Conclusion: Evidence indicates that micro-pollutants are strongly associated with impaired reproductive health. While causality cannot be definitively established due to observational study designs, the consistency of findings across populations, pollutants, and species highlights an urgent need for further research and regulatory measures to mitigate reproductive risks.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.