SynthesisFrontiers in oncology2025
Association between prognostic nutritional index and survival of patients with oral cancer: a meta-analysis.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Ninjin'yoeito is associated with attenuation of postoperative decline in Prognostic Nutritional Index in patients with oral squamous cell carcinoma: a single-center, open-label, single-arm study.Frontiers in nutrition · 2026Article
- Metabolic crosstalk between oral microbiota and the host in OSCC: emerging roles of microbial metabolites in tumor initiation and progression.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral cancer (OC) remains a major global health burden with unsatisfactory survival outcomes. The prognostic nutritional index (PNI), derived from serum albumin and lymphocyte counts, has been proposed as a simple biomarker of nutritional and immune status. This meta-analysis was performed to summarize the association between PNI and survival of patients with OC. We systematically searched PubMed, Embase, and Web of Science for longitudinal observational studies which compared low versus high PNI groups and reported hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) and/or progression-free survival (PFS). Pooled analyses were performed using random-effects models accounting for heterogeneity. A total of 16 cohorts were included. Low PNI was significantly associated with poorer OS (HR: 2.68, 95% CI: 2.00 to 3.58; I² = 64%) and PFS (HR: 1.99, 95% CI: 1.66 to 2.39; I² = 0%). Subgroup analyses revealed a stronger association in patients with mean age ≥ 65 years for both OS (HR: 3.49 vs. 1.48; Systematic review registration: PROSPERO, identifier CRD420251139755.
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