ArticleIranian journal of pharmaceutical research : IJPR
Biological Activities of Alkaloid Fraction of
Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Pharmacognostic Characterization, Phytochemical Profiling, and In Vitro Biological Evaluation ofInternational journal of molecular sciences · 2026Article
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9 authors.
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Abstract
Background: Objectives: The present study aims at a comprehensive characterization of the bulbs of Methods: Histochemical analysis was performed to localize alkaloids and other metabolites in the parenchyma cells of Results: Histochemical analysis confirmed the presence of alkaloids in the parenchyma cells of the bulbs, which also contained abundant starch granules. The HPTLC revealed a distinct fingerprint, highlighting the major alkaloids. The GC-MS profiling of the methanolic extract detected 16 fatty acids and other volatile components, with linoleic acid (40.86%) and palmitic acid (30.58%) as the dominant fatty acids, followed by linolenic acid (13.30%) and stearic acid (5.85%). The alkaloid-rich fraction contained 5α-cevan-3β,20-diol (19.65%) and fritillarin (18.86%) as prominent alkaloids. Their identification was confirmed by comparison with the National Institute of Standards and Technology (NIST) library, which showed high similarity scores [match factor (MF) = 890, reverse match factor (RMF) = 905 for 5α-cevane-3β, 20-diol; MF = 875, RMF = 900 for fritillarin]. The crude extract showed no detectable DPPH scavenging, antimicrobial, or cytotoxic activities under the tested conditions. In contrast, it demonstrated moderate ferric reducing capacity (1.0578), though lower than the reference standard gallic acid (1.8705). Conclusions: The bulbs of
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