Evidence map›Paper›PMID 41347521›Full record

ArticleAntimicrobial agents and chemotherapy2026

Efficacy assessments of EL219, a next-generation polyene antifungal, in immunosuppressed mice infected with drug-sensitive and drug-resistant

Eman G Youssef, Teclegiorgis Gebremariam, Yiyou Gu, Hoja Patterson, Sondus Alkhazraji, Tasneem Elsayed, Nathan P Wiederhold, Ashraf S Ibrahim

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eman G YoussefDivision of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center, Torrance, California, USA.ORCID 0000-0002-3167-1347
Teclegiorgis GebremariamDivision of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center, Torrance, California, USA.ORCID 0009-0005-6620-6401
Yiyou GuDivision of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center, Torrance, California, USA.ORCID 0000-0002-8295-7222
Hoja PattersonUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Sondus AlkhazrajiDivision of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center, Torrance, California, USA.
Tasneem ElsayedDivision of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center, Torrance, California, USA.
Nathan P WiederholdUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-2225-5122
Ashraf S IbrahimDivision of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center, Torrance, California, USA.ORCID 0000-0003-3787-8530

Funding

Novel Toxins and Receptors in Mucormycosis Pathogenesis and TreatmentR01AI063503 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI IBRAHIM, ASHRAF S. · 2006 to 2025
$7.3M
Project 3P01AI186818 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI DIMITRIOS P KONTOYIANNIS · 2025 to 2026
$6.7M
Elion Therapeutics 22775NIAID NIH HHS P01 AI186818NIAID NIH HHS R01 AI063503
6 · The paper itself

Abstract

Invasive pulmonary aspergillosis (IPA), mainly caused by

Indexed as

Antifungal AgentsAspergillusInvasive Pulmonary AspergillosisPolyenesAmphotericin BAnimalsAspergillus fumigatusDrug Resistance, FungalFemaleImmunocompromised HostLungMiceMice, Inbred ICRMicrobial Sensitivity TestsAmphotericin BAntifungal Agentsliposomal amphotericin BPolyenesantifungal agentsAspergillusEL219infection modelliposomal amphotericin BmurinepolyeneSF001

Identifiers

PMID41347521
PMCPMC12777570

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.