Trial reportJournal of cosmetic dermatology2025
Efficacy of the Combination Therapy of Intense Pulsed Light and Microneedling With a Postbiotic Formulation for Melasma.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Efficacy of the Combination Therapy of Intense Pulsed Light and Microneedling With a Postbiotic Formulation for Melasma.Journal of cosmetic dermatology · 2025Trial
- Localized follicular delivery of a JAK inhibitor using optimized PhosGlyNanoVes: a novel approach for alopecia areata treatment.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMelasma pathogenesis involves multifactorial mechanisms, and a comprehensive strategy achieves superior outcomes compared to monotherapy. Intense pulsed light (IPL) reduces pigmentation via selective photothermal effects, while microneedling enhances melanin clearance through mechanical stimulation and improves transdermal drug delivery. However, the therapeutic synergy of combining IPL with microneedling for melasma management requires further validation.
objectiveTo assess the clinical effectiveness of combining IPL and microneedling with a postbiotic formulation containing Lactobacillus fermentation lysate in facial melasma.
methodsThirty individuals were enlisted and randomly split into two groups. IPL therapy group: Received IPL treatments at 4-week intervals for 12 weeks. Combination therapy group: Underwent alternating IPL and microneedling every 2 weeks for 12 weeks. Symptomatic improvement was assessed utilizing the Modified Melasma Area and Severity Index (mMASI) Score and VISIA skin detection system (Canfield, USA). Patient satisfaction was evaluated through questionnaires.
resultsBoth groups showed significant mMASI score reductions from baseline, with greater improvement in the combination group (p < 0.05). Clinical photographs demonstrated decreased pigmentation and inflammation, with 73.3% of patients reporting satisfaction. VISIA analysis confirmed the significant decrease in the score of speckle, brown speckle, red region and UV speckle, further confirming the positive impact of the combination therapy on melasma. No severe adverse events occurred.
conclusionThe combination therapy of IPL and microneedling with a postbiotic formulation exhibits a multidimensional synergistic effect, presenting a promising new direction for melasma therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.