Evidence map›Paper›PMID 41347619›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Novel Vascularized Human Liver Organoids for Modeling Alcohol-Induced Liver Injury and Developing Hepatoprotective Therapy.

Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih-Tsung Yang, Xiaohui Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kangdi YangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Xiayan ChuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Xuerui WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Wenkun ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Jinnuo LuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Chuting XuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Shoucheng HuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Guoyu PanShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Chih-Tsung YangFuture Industries Institute, University of South Australia, Mawson Lakes Campus, Adelaide, SA, 5095, Australia.
Xiaohui ZhangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Shaojin LiState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Zhaobin GuoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Hanyang LiuDepartment of Hepatology and Gastroenterology, Campus Virchow- Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.
Guangbo GeState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.ORCID https://orcid.org/0000-0002-9670-4349

Funding

National Natural Science Foundation of China 81922070National Natural Science Foundation of China 82104281National Natural Science Foundation of China 82273897National Natural Science Foundation of China 82300730National Natural Science Foundation of China 82304446National Natural Science Foundation of China U23A20516Noncommunicable Chronic Diseases-National Science and Technology Major Project 2025ZD0546900Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine 2023YZZ02State Key Laboratory of Fine Chemicals, Dalian University of Technology KF2202State Key Laboratory of Fine Chemicals, Dalian University of Technology KF2414
6 · The paper itself

Abstract

Liver organoids have emerged as transformative tools for disease modeling and therapy development. However, their inability to form functional multivascular networks significantly limits their capacity to replicate the multifaceted functions of the native human liver with high fidelity. Here, novel vascularized liver organoids (3HLOs) are constructed by co-culturing robust human reprogrammed hepatocyte-like cells (hrHLs) with endothelial cells (HUVECs) and mesenchymal stem cells (HUMSCs) in a 3D system. After optimization, 3HLOs form vascular architecture featuring CD31

Indexed as

Chemical and Drug Induced Liver InjuryLiverOrganoidsAnimalsCoculture TechniquesDisease Models, AnimalEthanolHepatocytesHumansMesenchymal Stem CellsMiceEthanolalcoholic liver injury (ALI)drug screeningliver organoidsorganoid therapyvascularization

Identifiers

PMID41347619
PMCPMC12904048

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.