Evidence map›Paper›PMID 41347831›Full record

ArticleOncology reports2026

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma.

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuto KitanoDepartment of Hepato‑Biliary‑Pancreatic Surgery and Transplantation/Pediatric Surgery, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan.
Tomoharu MiyashitaDepartment of Hepato‑Biliary‑Pancreatic Surgery and Transplantation/Pediatric Surgery, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan.
Takeo ShimasakiMedical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920‑0293, Japan.
Isamu MakinoDepartment of Hepato‑Biliary‑Pancreatic Surgery and Transplantation/Pediatric Surgery, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan.
Yoshio EndoCentral Research Resource Branch, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920‑1192, Japan.
Yasuhiko YamamotoDepartment of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan.
Noriyuki InakiDepartment of Gastrointestinal Surgery/Breast Surgery, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan.
Shintaro YagiDepartment of Hepato‑Biliary‑Pancreatic Surgery and Transplantation/Pediatric Surgery, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrous stroma, within which a subset of fibroblasts function as cancer‑associated fibroblasts (CAFs) and contribute to tumor progression. Some of these fibroblasts undergo senescence and promote malignancy through the senescence‑associated secretory phenotype (SASP). The present study investigated SASP factor expression in senescent fibroblasts within the PDAC microenvironment and evaluated their impact on tumor progression. The expression levels of the senescence marker p16 and the SASP factor interleukin‑6 (IL‑6) were assessed using fluorescence immunostaining in resected specimens from 90 patients with PDAC who underwent pancreaticoduodenectomy. Senescence was induced in primary human pancreatic fibroblasts via X‑ray irradiation

Indexed as

Cancer-Associated FibroblastsCarcinoma, Pancreatic DuctalInterleukin-6Pancreatic NeoplasmsSenescence-Associated Secretory PhenotypeAdultAgedAged, 80 and overBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationCellular SenescenceCoculture TechniquesCyclin-Dependent Kinase Inhibitor p16FemaleBiomarkers, TumorCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16IL6 protein, humanInterleukin-6fibroblastspancreatic ductal adenocarcinomaprognosissenescencesenescence‑associated secretory phenotype

Identifiers

PMID41347831
PMCPMC12699291

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.