ArticleBrain informatics2025
Boosting brain tumor detection with an optimized ResNet and explainability via Grad-CAM and LIME.
Article in Brain informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- CAE-BrainNet: a statistically validated class-adaptive attention ensemble model for explainable brain tumor classification from MRI.Brain informatics · 2026Article
- A multicenter-validated interpretable transformer model for pituitary microadenoma detection on non-contrast multiparametric MRI.BMC medical imaging · 2026Article
- BrainFusionNet: a deep learning and XAI model to understand local, global, and sequential features of MRI images for improved brain tumour detection.Brain informatics · 2026Article
- Multimodal deep learning outperforms clinical and brain region models in predicting stroke-associated pneumonia: an explainable AI study.Frontiers in neurology · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
Detecting Brain Tumors is essential in medical imaging, as early and accurate diagnosis significantly improves treatment decisions and patient outcomes. Convolutional Neural Networks have demonstrated high efficiency in this domain, but their lack of interpretability remains a significant drawback for clinical adoption. This study explores the integration of Explainability techniques to enhance transparency in CNN-based classification and improve model performance through advanced optimization strategies. The primary research question addressed is how to improve the accuracy, generalization, and interpretability of CNNs for brain tumor Detection. While previous studies have demonstrated the effectiveness of deep learning for tumor detections, challenges such as class imbalance and overfitting of CNNs persist. To bridge this gap, we employ different dynamic learning rate modifiers, perform architectural enhancements, and apply XAI techniques, including Grad-CAM and LIME. Our experiments are conducted on three publicly available multiclass tumor datasets to ensure the generalizability of the proposed approach. Among the tested architectures, the enhanced ResNet model consistently outperformed others across all datasets, achieving the highest test accuracy, ranging from 99.36% to 99.65%. The techniques such as unfreezing layers, integrating various blocks, pooling, and dropout layers enhanced feature refinement and reduced overfitting. By incorporating XAI, we improve model interpretability, ensuring that clinically relevant regions in MRI scans are highlighted. These advancements contribute to highly reliable AI-assisted diagnostics, addressing significant challenges in medical image classification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.