Evidence map›Paper›PMID 41348295›Full record

ReviewMolecular neurobiology2025

Navigating the Lipid Landscape: The Role of Fatty Acid Synthase in Neural Stem Cell Fate and Central Nervous System Function.

Reena Gupta, Abdulwahab Mahmood Abdulazeez, Monthar Kedhim, Ali G Alkhathami, Malathi H, Mayank Kundlas, Laxmidhar Maharana, Ashish Singh Chauhan, Mohammed Jawad Alnajar, Hayder Abdulhasan Hammoodi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Reena GuptaInstitute of Pharmaceutical Research, GLA University, Mathura, U.P, 281406, India. rspg80@gmail.com.
Abdulwahab Mahmood AbdulazeezCollege of Pharmacy, University of Al Maarif, Al Anbar, 31001, Iraq. Abdulwahab.Mahmood@uoa.edu.iq.
Monthar KedhimCollege of Pharmacy, The Islamic University, Najaf, Iraq.
Ali G AlkhathamiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Malathi HDepartment of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Mayank KundlasCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, 140401, India.
Laxmidhar MaharanaDepartment of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, 751030, India.
Ashish Singh ChauhanDivision of Research and Innovation, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.
Mohammed Jawad AlnajarDepartment of Pharmacy, Al-Nisour University College, Nisour Seq. Karkh, Baghdad, Iraq.
Hayder Abdulhasan HammoodiMazaya University College, Nasiriyah, Dhi Qar, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipids play a critical role in both the brain's structure and function by serving as a primary component of cell membranes and myelin sheaths. They help impart structural stability and fluidity to neuronal membranes that are crucial to synaptic plasticity and signal transduction. Importantly, the equilibrium between lipid production and degradation dictates a stem cell's fate. Lipid metabolism is an essential controller that affects how a stem cell commits to a particular cell lineage by differentiating into a specific cell type or staying undifferentiated and self-renewing. In order to maintain an elevated level of proliferation, cancer cells frequently exhibit an increased de novo lipogenesis (DNL) flow. Most malignancies overexpress the DNL enzyme fatty acid synthase (FAS), which is essential for fatty acid synthesis. There is mounting proof suggesting that FAS has a role in various cancer-related features, which are connected to its capacity to stimulate cell proliferation through the production of membranes. Beyond structural roles, lipids act as signaling molecules, including second messengers like diacylglycerol and arachidonic acid derivatives, which modulate neurotransmitter release. Moreover, this enzyme plays a pivotal role in adult stem cells, especially in neural stem cells (NSCs). This review aimed to study the role of lipids and FAS in CNS biological functions and pathological effects. Also, we delve into the role of FAS in NSC behavior to better elucidate the effects of this enzyme on the fate of such stem cells.

Indexed as

Central Nervous SystemFatty Acid SynthasesLipid MetabolismNeural Stem CellsAnimalsCell DifferentiationHumansFatty Acid SynthasesFASLipidsMetabolismNeurogenesisNSCs

Identifiers

PMID41348295

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.