Evidence map›Paper›PMID 41348420›Full record

ArticleMolecular neurobiology2025

Metformin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage Via Improving Endoplasmic Reticulum Stress and Mitochondrial Stress-Mediated Ca

Zhonghua Zhang, Jingbei Zhang, Liping Li, Lin Zong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhonghua Zhang *Department of Anesthesiology, Jinling School of Clinical Medicine, Jinling Hospital, Nanjing Medical University, Jiangsu, 210000, China.
Jingbei Zhang *The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510000, China.
Liping LiDepartment of Anesthesiology, Jinling School of Clinical Medicine, Jinling Hospital, Nanjing Medical University, Jiangsu, 210000, China. 2020250318@stu.njmu.edu.cn.
Lin ZongDepartment of Anesthesiology, Jinling School of Clinical Medicine, Jinling Hospital, Nanjing Medical University, Jiangsu, 210000, China. 15295518988@163.com.

Funding

China Postdoctoral Science Foundation 2024M754280
6 · The paper itself

Abstract

Subarachnoid hemorrhage (SAH) is a destructive subtype of stroke characterized by a high mortality and morbidity rate (45-50%) and a poor neurologic prognosis, encompassing both neurological and psychiatric impairments. It will be more imperative to explore new therapeutic strategies for early brain injury (EBI) to enhance the prognosis of patients with SAH. First, we investigated the role of endoplasmic reticulum stress (ERS) and mitochondrial stress (MS) in mediating the IP3R1-GRP75-VDAC1 Ca

Indexed as

Brain InjuriesCalciumEndoplasmic Reticulum StressMetforminMitochondriaSubarachnoid HemorrhageAnimalsApoptosisBrain EdemaInositol 1,4,5-Trisphosphate ReceptorsMaleMiceMice, Inbred C57BLVoltage-Dependent Anion Channel 1CalciumInositol 1,4,5-Trisphosphate ReceptorsMetforminVoltage-Dependent Anion Channel 1ApoptosisCa2+Early brain injuryMetforminSubarachnoid hemorrhage

Identifiers

PMID41348420
PMCPMC12680679

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.