ReviewNature cardiovascular research2025
Development and modeling of cardiac autonomic innervation.
Review in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Autonomic innervation is important for heart development and function, as well as for the response to injury and hemodynamic stress. However, the mechanisms underlying neurocardiac interactions are difficult to investigate in vivo, prompting the need for advanced engineering of in vitro models of innervated cardiac tissues. Here, we review the embryonic development of the heart and postganglionic autonomic neurons and discuss the functional consequences of cardiac autonomic innervation, focusing on its trophic roles in neonatal and adult hearts. We highlight methods for generating functional cardiomyocytes and autonomic neurons from human pluripotent stem cells and discuss the benefits and limitations of existing in vivo and in vitro cardiac innervation models. Lastly, we present a roadmap for the development of high-fidelity, mature pluripotent stem cell-derived models of cardiac autonomic innervation to address outstanding questions in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.