Evidence mapPaperPMID 41350491Full record

ArticleTranslational psychiatry2025

Associations between chronotype and psychiatric symptoms across the adult lifespan.

John Axelsson, Leonie Jt Balter

Abstract read
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Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

John AxelssonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-3932-7310
Leonie Jt BalterDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. leonie.balter@ki.se.ORCID http://orcid.org/0000-0002-3083-7456

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronotype, the individual propensity towards morningness or eveningness, is a transdiagnostic factor implicated in mental health. How chronotype covaries with distinct psychiatric symptoms across the adult lifespan remains underinvestigated. In this cross-sectional study, 428 participants (18-70 years, evenly distributed across five age groups; 282 women, 143 men, other gender identity) completed the Reduced Morningness-Eveningness Questionnaire to approximate chronotype, and 11 validated scales assessing common psychiatric symptoms. Regression analyses and generalized additive models (GAMs) were used to examine linear and nonlinear relationships between chronotype, age, and psychiatric symptoms. Eveningness was associated with (in decreasing order of strength): emotion dysregulation, attention-deficit/hyperactivity disorder (ADHD), depression, autism, emotional instability, generalized anxiety, social anxiety, and impulsivity symptoms. Morningness was associated with mania symptoms. No significant associations were found between chronotype and delusional ideation or obsessive compulsive disorder (OCD) symptoms. Psychiatric symptom severity was generally lower with increasing age, particularly for emotional instability, emotion dysregulation, and ADHD. Nonetheless, certain symptoms persisted across age in eveningness (depression, generalized anxiety, OCD, ADHD), while other symptoms were lower (mania) or higher (social anxiety and delusional ideation) with eveningness at older ages. Except for mania symptoms, morningness in older age was not associated with higher symptom burden than eveningness for any other psychiatric domains. These results are consistent with the idea that morningness may be protective, being associated with lower psychiatric symptom levels in both younger and older age groups. In contrast, eveningness was associated with higher levels of autism, social anxiety and delusional ideation symptoms in older age.

Indexed as

Circadian RhythmMental DisordersAdolescentAdultAgedAge FactorsChronotypeCross-Sectional StudiesFemaleHumansMaleMiddle AgedSurveys and QuestionnairesYoung Adult

Identifiers

PMID41350491
PMCPMC12689609

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.