ArticleScientific reports2025
Spontaneous refractive error, ocular biometry and age related lens changes in a population of geriatric rhesus macaques.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Aging of Nonhuman Primate Eyes Is Sexually Dimorphic.Investigative ophthalmology & visual science · 2026Article
- AFrontiers in cell and developmental biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
The purpose of this investigation was to determine refractive error, ocular biometry and age-related lens changes in a population of geriatric rhesus macaques (Macaca mulatta) from the California National Primate Research Center (CNPRC). Ophthalmic examination was performed in 182 rhesus macaques [Formula: see text] 19 years of age using a cross-sectional study design, including streak retinoscopy, anterior segment tomography, A-scan ultrasound biometry and handheld slit lamp biomicroscopy. Median spherical equivalent refractive error was + 0.75 D with an interquartile range (IQR) of 0 to 1 D. Most eyes were hyperopic (n = 102, 55%) or emmetropic (n = 68, 36%); myopic eyes were the least common (n = 17, 9%). Anisometropia was present in 13 subjects (14%). Mean (± SD) corneal curvature was 52.6 ± 2.6 D (n = 79). Mean (± SD) axial globe length was 20.2 ± 1.5 mm, anterior chamber depth was 3.7 ± 0.4 mm, lens thickness was 4.1 ± 0.4 mm, and vitreous chamber depth was 12.2 ± 1.0 mm (n = 86). Median (IQR) nuclear sclerosis grade (n = 191, 98%) assessed with the lens opacities classification system II was 1 (1-2). Hyperopia is the most common refractive error in the geriatric rhesus macaque population at CNPRC. This study provides reference values for an isolated geriatric rhesus macaque population and broadens our understanding of refractive error and lens opacities in geriatric rhesus macaques which may serve as a model for studying novel therapeutics for refractive errors and cataracts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.