ArticleScientific reports2025
Association between blood urea nitrogen-to-creatinine ratio and 28-day mortality in acute kidney injury patients undergoing continuous renal replacement therapy.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
This study aims to investigate the association between the blood urea nitrogen-to-creatinine (BUN/Cr) ratio and 28-day mortality in critically ill patients with acute kidney injury (AKI) who received continuous renal replacement therapy (CRRT). We conducted a retrospective cohort study using data from the DATADRYAD database ( www.datadryad.org ). The study population was divided into four groups based on the quartiles of BUN/Cr levels measured prior to the initiation of CRRT. Multivariate Cox proportional hazards models and Kaplan-Meier analysis were used to assess this relationship, while restricted cubic spline (RCS) analysis was utilized to explore potential non-linear associations. Additionally, subgroup analysis was conducted to assess consistency across groups. A total of 1,137 critically ill patients with AKI who received CRRT were included. The highest BUN/Cr quartile demonstrated a significantly increased mortality risk (HR: 1.66, 95% CI: 1.34-2.06, p < 0.001) compared to the lowest quartile. Multivariate Cox regression analysis revealed that, even after adjusting for potential confounders, an elevated BUN/Cr ratio remained a significant and independent predictor of increased 28-day mortality. RCS analysis revealed a J-shaped relationship (p for nonlinearity < 0.001) between the BUN/Cr ratio and 28-day mortality, with a sharp increase in the risk of death above the threshold of 15.0. Subgroup analysis confirmed consistency across most subgroups, except for patients with hypertension (p for interaction = 0.035), where the association was stronger in individuals with hypertension. Higher BUN/Cr ratios are independently associated with increased 28-day mortality in AKI patients who received CRRT, exhibiting a non-linear relationship. The BUN/Cr ratio may serve as a cost-effective and accessible prognostic marker for this population, helping to identify high-risk patients for targeted interventions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.