SynthesisBMC surgery2025
Surgical outcomes of simultaneous vs. staged resection in colorectal cancer with liver metastases: a systematic review and meta-analysis.
Synthesis in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
BACKGROUND AND
objectiveColorectal cancer is among the most common global malignancies. Approximately 25% of patients present with liver metastases at diagnosis. Debate persists over whether to choose simultaneous or staged resection due to the varying evidence regarding outcomes and patient eligibility criteria for each approach. This study aims to assess and compare both short- and long-term surgical outcomes of simultaneous and staged resection approaches.
methodsWe performed a systematic review and meta-analysis of 18 articles published from 2000 to 2024 on PubMed and Web of Science, to compare outcomes between the two methods for patients with colorectal cancer and liver metastases.
resultsSimultaneous resection showed no statistically significant difference in hospital stay compared with staged resection (MD - 1.07 days, 95% CI - 8.00 to 5.85; P = 0.76; I² = 98%). Morbidity was also similar (OR 0.92, 95% CI 0.75-1.13; P = 0.41). Overall mortality was higher after staged resection (OR 1.96, 95% CI 1.24-3.09; P = 0.004). Differences in 30- and 90-day mortality, postoperative complications, and recurrence were not statistically significant, with wide confidence intervals and considerable heterogeneity across studies.
conclusionSimultaneous resection of colorectal cancer with liver metastases appears safe and feasible in appropriately selected patients, with no statistically significant differences in hospital stay, complications, recurrence, or short-term mortality when compared with staged resection. Although some outcomes showed directional trends favoring simultaneous surgery, these findings were not statistically significant and were affected by high heterogeneity. Careful patient selection remains essential, and further high-quality studies are needed to better define candidates most likely to benefit from either approach.
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