SynthesisAddiction science & clinical practice2025
The effects of glucagon-like peptide-1 receptor agonists (GLP1-RAs) on alcohol-related outcomes: a systematic review and meta-analysis.
Synthesis in Addiction science & clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Glucagon-like Peptide-1 Receptor Agonists and Alcohol Use Outcomes: A Systematic Review of Clinical Evidence.Journal of clinical medicine · 2026Review
- Glucagon-like peptide 1 receptor agonists in substance use disorders: A systematic review of ClinicalTrials.Gov.Addictive behaviors reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on alcohol-related outcomes in adults with or without alcohol use disorder (AUD).
methodsA systematic review and meta-analysis following PRISMA guidelines searched PubMed, Embase, and Cochrane Library up to May 3, 2025. Eligible studies included randomized controlled trials (RCTs) and observational studies assessing GLP-1RAs (e.g., Semaglutide, Liraglutide, Exenatide, and Dulaglutide) versus placebo, no treatment, or other interventions in adults. Outcomes were alcohol consumption (defined as total intake or drinks per drinking day, measured as standardised mean difference [SMD]), alcohol craving (SMD), and alcohol-related events (hazard ratio [HR]). Random-effects models with Restricted Maximum Likelihood estimation and Hartung-Knapp adjustment were used. Separate AUD and SUD meta-analyses addressed outcome heterogeneity, with intoxication reported narratively.
resultsThree RCTs (N = 430) and six observational studies (N = 2,740,207) were included. RCTs showed non-significant reductions in alcohol consumption (SMD: -0.24, 95% CI: -0.70, 0.23), drinks per drinking day (SMD: -0.23, 95% CI: -0.64, 0.19), and craving (SMD: -0.14, 95% CI: -2.84, 2.55), with Semaglutide showing greater craving reduction (p = 0.024). Observational studies showed reduced alcohol-related events (HR: 0.64, 95% CI: 0.59-0.69, p < 0.001), with separate analyses confirming effects for AUD (HR: 0.66, 95% CI: 0.63-0.70) and SUD (HR: 0.66, 95% CI: 0.18-2.48), and intoxication (HR: 0.50). Semaglutide and GIP/GLP-1RAs had more potent effects (p < 0.001).
conclusionObservational studies suggest a decrease in alcohol-related events, but RCTs have effects on alcohol consumption and craving that remain non-significant. Larger RCTs are needed. PROSPERO ID: CRD420251045294.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.