Trial reportNutrition journal2025
Effects of combined nutritional supplementation and exercise on proxy measures of muscle mass, strength, and function in older adults with sarcopenia: a 12-week multicentre RCT.
Trial report in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Vitamin D as a Modulator of Sarcopenia in Women: Interactions with Dietary Patterns and Physical Exercise.Nutrients · 2026Review
- Feasibility of social media health education plus exercise in older adults with possible sarcopenia.NPJ digital medicine · 2026Article
- Research progress on the molecular mechanism and clinical evidence of glucagon-like peptide-1 receptor agonists in improving sarcopenia.Diabetology & metabolic syndrome · 2026Review
- Chinese expert consensus on dietary nutrition prescriptions and exercise intervention for sarcopenia (2025).Asia Pacific journal of clinical nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough nutritional supplementation and exercise have shown independent efficacy in managing sarcopenia, data supporting their combined implementation in real-world clinical settings remain limited.
methodsThis 12-week multicenter randomized controlled trial enrolled 110 older adults (≥ 65 years) with sarcopenia or possible sarcopenia. Participants were randomly allocated (1:1) to either the intervention group (n = 55) or control group (n = 55). In addition to their habitual diets, the intervention group received daily muscle-targeted oral nutritional supplementation (MT-ONS, 2 × 10 g sachets/day: containing 8.4 g protein, 0.5 g calcium β-hydroxy-β-methylbutyrate, 200 IU D3 per sachet) alongside a structured exercise programs featuring twice-weekly resistance training (20 min/session), alternate-day chair-based exercises (10 min/session), and home-based activity recommendations. Control group participants maintained their habitual dietary and physical activity patterns without intervention. All outcome measures were assessed at baseline and post-intervention.
resultsThe intervention group showed modest increases in BIA-derived appendicular lean tissue (mean change + 0.60 kg, 95% CI 0.33 to 0.88), skeletal muscle index (+ 0.20 kg/m², 95% CI 0.11 to 0.29), and handgrip strength (+ 2.22 kg, 95% CI 1.35 to 3.09) compared with the control group. Improvements were also observed in walking speed, chair-stand performance, Short Physical Performance Battery scores, serum vitamin D, and EQ-5D measures of quality of life.
conclusionA 12-week combined intervention of multi-ingredient nutritional supplementation and exercise led to modest improvements in proxy measures of muscle mass, strength, function, and quality of life in older adults. As muscle mass was not directly measured and the study did not employ a factorial design, the relative contributions of exercise and supplementation cannot be determined. These findings suggest that combined interventions may help attenuate, rather than reverse, sarcopenia-related decline.
trial registrationThis clinical trial was registered on Chinese Clinical Trial Registry (ChiCTR2300077187) on 1 November 2023.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.