ArticleNPJ digital medicine2025
Metabolomic characterization of frailty identifies subtype-specific management strategies.
Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Bridging geriatrics and trauma: Evidence-based care for falls in older adults.Clinical medicine (London, England) · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
The clinical application of the frailty phenotype and frailty index still has some limitations, and whether the classification of frailty based on metabolites is beneficial to the management of the frailty population remains unclear. This study analyzed 160,407 UK Biobank participants to define frailty subtypes using metabolic profiles. Based on 251 biomarkers, machine learning identified 11 key metabolites, leading to four novel frailty subtypes. Subtypes III and IV, characterized by adverse metabolic features such as high GlycA and low LA/FA, were designated as high-risk groups. These subtypes showed significantly increased risks for 13 chronic diseases and all-cause mortality compared to lower-risk subtypes. Adherence to a healthy diet was associated with risk reduction in the high-risk groups. These findings demonstrate the heterogeneity of frailty and suggest that metabolite-based subtyping could improve prognostic precision and guide targeted dietary interventions in clinical practice.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.