ArticleCommunications biology2025
A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS.
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Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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Who cites it
1 citing paper in PubMed.
- Human iPSC‑based translational and reverse translational research for neurodegenerative diseases: emphasis on ALS and key advances.Japanese journal of radiology · 2026Review
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Authors and funding
49 authors.
Ryoichi Nakamura *Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan.ORCID http://orcid.org/0000-0002-4854-3579
Genki Tohnai *Division of ALS Research, Aichi Medical University School of Medicine, Nagakute, Japan.
Naoki Atsuta *Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan.
Yumi Matsuda *Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0009-0009-2312-0842
Satoru MorimotoKeio University Regenerative Medicine Research Center, Kawasaki, Japan.
Daisuke ItoDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masahisa KatsunoDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0001-9453-9311
Yuishin IzumiDepartment of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Mitsuya MoritaDivision of Neurology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Ikuko IwataDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Ichiro YabeDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.ORCID http://orcid.org/0000-0002-1734-7997
Tomoko NakazatoDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Nobutaka HattoriDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2034-2556
Takehisa HirayamaDepartment of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.
Osamu KanoDepartment of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.
Asako TamuraDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, Japan.
Naoki SuzukiDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID http://orcid.org/0000-0001-8880-8554
Masashi AokiDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID http://orcid.org/0000-0001-7284-1069
Kazumoto ShibuyaDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Satoshi KuwabaraDepartment of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masaya OdaDepartment of Neurology, Vihara Hananosato Hospital, Miyoshi, Japan.
Rina HashimotoDepartment of Neurology, NHO Higashinagoya National Hospital, Nagoya, Japan.
Ikuko AibaDepartment of Neurology, NHO Higashinagoya National Hospital, Nagoya, Japan.
Tomohiko IshiharaDepartment of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
Osamu OnoderaDepartment of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.ORCID http://orcid.org/0000-0003-3354-5472
Toru YamashitaDepartment of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.ORCID http://orcid.org/0000-0003-3634-5679
Hiroyuki IshiuraDepartment of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Kota BokudaDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
Toshio ShimizuDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
Yoshio IkedaDepartment of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Kazuko HasegawaDivision of Neurology, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.
Fumiaki TanakaDepartment of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Takanori YokotaDepartment of Neurology and Neurological Science, NucleoTIDE and PepTIDE Drug Discovery Center (TIDE), Institute of Science Tokyo, Tokyo, Japan.
Kazuaki KanaiDepartment of Neurology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Yu-Ichi NotoDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ryuji KajiDepartment of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.ORCID http://orcid.org/0000-0001-6207-1080
Hirohisa WatanabeDepartment of Neurology, Fujita Health University, Toyoake, Japan.
Tomoko KonishiDivision of ALS Research, Aichi Medical University School of Medicine, Nagakute, Japan.
Mikiko HasegawaDivision of ALS Research, Aichi Medical University School of Medicine, Nagakute, Japan.
Hozuki FukayaDivision of ALS Research, Aichi Medical University School of Medicine, Nagakute, Japan.
Jun-Ichi NiwaDepartment of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan.ORCID http://orcid.org/0000-0002-7137-4662
Manabu DoyuDepartment of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan.
Yohei OkadaDepartment of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan.ORCID http://orcid.org/0000-0001-5253-8556
Shiho NakamuraKeio University Regenerative Medicine Research Center, Kawasaki, Japan.
Fumiko OzawaKeio University Regenerative Medicine Research Center, Kawasaki, Japan.
Hideyuki OkanoKeio University Regenerative Medicine Research Center, Kawasaki, Japan.ORCID http://orcid.org/0000-0001-7482-5935
Masahiro NakatochiPublic Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan. mnakatochi@met.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0002-1838-4837
Gen SobueDivision of ALS Research, Aichi Medical University School of Medicine, Nagakute, Japan. sobueg@aichi-med-u.ac.jp.ORCID http://orcid.org/0000-0003-4769-5922
Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group
Funding
Japan Agency for Medical Research and Development (AMED) JP19km0405216Japan Agency for Medical Research and Development (AMED) JP23bm1123046, JP23kk0305024, JP23bm1423002Japan Agency for Medical Research and Development (AMED) JP23ek0109492, JP23ak0101111, JP23ak0101124, JP24wm0425009Japan Agency for Medical Research and Development (AMED) JP23ek0109538Japan Agency for Medical Research and Development (AMED) JP24ak0101216, JP24ak0101222, JP25wn0625519, JP25ak0101216, JP25ak0101222, JP25ek0109617Japan Agency for Medical Research and Development (AMED) JP24bm1423003MEXT | Japan Society for the Promotion of Science (JSPS) 16H06277MEXT | Japan Society for the Promotion of Science (JSPS) 19K06523MEXT | Japan Society for the Promotion of Science (JSPS) 19K07973MEXT | Japan Society for the Promotion of Science (JSPS) 21H05278MEXT | Japan Society for the Promotion of Science (JSPS) 22H02988MEXT | Japan Society for the Promotion of Science (JSPS) 22H03350MEXT | Japan Society for the Promotion of Science (JSPS) 22H04923MEXT | Japan Society for the Promotion of Science (JSPS) 22K07359MEXT | Japan Society for the Promotion of Science (JSPS) 22K07509MEXT | Japan Society for the Promotion of Science (JSPS) 23K06835MEXT | Japan Society for the Promotion of Science (JSPS) 23K06975MEXT | Japan Society for the Promotion of Science (JSPS) 23K24249MEXT | Japan Society for the Promotion of Science (JSPS) 25K10781Ministry of Health, Labour and Welfare (Ministry of Health, Labour and Welfare, Japan) 23FC0201
Abstract
Amyotrophic lateral sclerosis (ALS) exhibits considerable clinical variability, such as differences in age at onset (AAO). Multiple factors, including genetic factors, may underlie this variability; however, the specific determinants remain unclear. To identify genes affecting AAO, we have conducted a genome-wide association study in Japanese patients with ALS (discovery cohort: n = 1808; replication cohort: n = 207). Here, we show that the minor A allele of rs113161727 at the ADAM29-GPM6A locus is associated with a younger AAO in the discovery cohort (effect, -4.27 years; p = 4.60 × 10
Indexed as
Amyotrophic Lateral SclerosisGenome-Wide Association StudyGPI-Linked ProteinsAdultAgedAge of OnsetFemaleGenetic Predisposition to DiseaseHumansJapanMaleMiddle AgedPolymorphism, Single NucleotideGPI-Linked Proteins
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.