Evidence map›Paper›PMID 41350871›Full record

SynthesisBMC medicine2025

Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis.

Fernando Sebastian-Valles, Sergio Núñez de Arenas-Arroyo, Olga Simó-Servat, Rafael Simó, Helena Painter, Jose Alfonso Arranz Martín, Victor Navas-Moreno, Mónica Marazuela, Vicente Martínez-Vizcaíno, Julia Martínez-Alfonso

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fernando Sebastian-VallesDepartment of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IIS-Princesa), Madrid, 28006, Spain.
Sergio Núñez de Arenas-ArroyoHealth and Social Care Research Center, Universidad de Castilla-La Mancha, 16071, Cuenca, Spain. Sergio.NunezdeArenas@uclm.es.
Olga Simó-ServatDiabetes and Metabolism Research Unit, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
Rafael SimóDiabetes and Metabolism Research Unit, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
Helena PainterWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Jose Alfonso Arranz MartínDepartment of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IIS-Princesa), Madrid, 28006, Spain.
Victor Navas-MorenoDepartment of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IIS-Princesa), Madrid, 28006, Spain.
Mónica MarazuelaDepartment of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IIS-Princesa), Madrid, 28006, Spain.
Vicente Martínez-VizcaínoHealth and Social Care Research Center, Universidad de Castilla-La Mancha, 16071, Cuenca, Spain.
Julia Martínez-AlfonsoDepartment of Family and Community Medicine, Centro de Salud Daroca, 28006, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite improvements in screening and diabetes management, diabetic retinopathy (DR) remains a leading cause of vision loss in individuals with type 1 diabetes (T1D). Although clinical risk factors for DR are well established, the impact of socioeconomic status (SES) on DR risk remains poorly defined. The objective of this study was to estimate the association between SES and DR in people with T1D.

methodsWe searched MEDLINE, Scopus, and Web of Science from inception to May 2025 for observational studies evaluating the association between SES and DR prevalence or incidence in individuals with T1D. Two reviewers independently performed study selection, data extraction, and risk of bias assessment using the ROBINS-E tool. Random-effects meta-analyses were conducted using the Sidik-Jonkman method. Subgroup analyses were performed by DR severity, SES measurement level, geographic region, and study design. Certainty was graded using the GRADE framework.

resultsTwenty-two studies including 69,446 individuals from 13 countries were included. Low SES was significantly associated with higher DR risk (OR = 1.44; 95% CI: 1.21-1.71; I

conclusionsSocioeconomic disadvantage is a significant and clinically relevant risk factor for DR in individuals with T1D. The effect appears more pronounced for advanced stages. Integrating SES into DR risk stratification models and screening strategies may be essential to promote equity and reduce preventable vision loss. PROSPERO REGISTRATION: CRD420251034446.

Indexed as

Diabetes Mellitus, Type 1Diabetic RetinopathySocial ClassHumansPrevalenceRisk FactorsDiabetic retinopathySocioeconomic statusType 1 diabetes

Identifiers

PMID41350871
PMCPMC12798038

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.