ArticleMicrobial cell factories2025
High hydrostatic pressure enhances chitinase activity and reveals metabolic regulation via transcriptomics in an abyssal fungus Purpureocillium lilacinum FDZ8Y1.
Article in Microbial cell factories, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Hyaluronic acid degradation by Purpureocillium lilacinum: biochemical and transcriptomic insights.Applied microbiology and biotechnology · 2026Article
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Abstract
backgroundThe abyssal environment is characterized by extreme conditions such as high hydrostatic pressure (HHP), low temperature, and high salinity, which affects the protein synthesis of filamentous fungi. The targeted extracellular enzyme regulation mechanism plays a key role in maintaining its survival and colonization in extreme environments. Compared to prokaryotes, studies on the characteristics of extracellular enzymes in abyssal fungi and their role in carbon-nitrogen coupling metabolism remain limited. In this study, we systematically explored the chitinase-producing activity and catalytic efficiency of Purpureocillium lilacinum FDZ8Y1, a filamentous fungus derived from sediments in the Mariana Trench, in different environments. Transcriptome analysis was used to further investigate the changes of chitinase-related energy metabolism in response to HHP.
resultsThrough gradient environmental stress assays (temperature/salinity/HHP) and comparative enzymatic profiling with congeneric strains, P. lilacinum FDZ8Y1 demonstrates remarkable cold tolerance, salt tolerance, and pressure-responsive characteristics in both enzyme production and catalytic efficiency. Transcriptomic analysis revealed that the genes encoding chitinases and the metabolic activities related to chitin degradation and utilization play a pivotal role in the response of this fungus to HHP. HHP stimulation activated the expression of chitinase gene in this fungus, the regulation of cell wall components, as well as key metabolic pathways such as glycolytic - galactose metabolism, fatty acid β -oxidation, and nitrate reductase-mediated nitrogen metabolism.
conclusionsOur research identified the excellent chitinase activity characteristics of P. lilacinum FDZ8Y1 under low temperature and high pressure, identified the metabolic pathway transformation of this fungus in response to HHP, explored the metabolic response models related to chitin degradation and utilization under these conditions, and further analyzed the functional correlations of these metabolic adaptations. This information provides a new idea and direction for further understanding the functional adaptability of deep-sea fungi and exploring the enzyme resources of deep-sea microorganisms.
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