Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Fangfang YiHepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, Zhejiang, China.ORCID http://orcid.org/0000-0003-0021-823X
Jinyong WangHepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, Zhejiang, China.ORCID http://orcid.org/0000-0002-8996-1398
Yi ChenHepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, Zhejiang, China.ORCID http://orcid.org/0000-0002-3788-0684
Yuanhang XiaSchool of Clinical Medicine, The First People's Hospital of Lin'an Distract, Hangzhou, Lin'an People's Hospital Affiliated to Hangzhou Medical College, Hangzhou Medical College, Hangzhou, Zhejiang, China.ORCID http://orcid.org/0009-0005-5835-2396
Hongfei ZhouHepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, Zhejiang, China.ORCID http://orcid.org/0000-0002-4655-3837
Yujuan ShenHepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, Zhejiang, China.
Sizhe FangHepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, Zhejiang, China.ORCID http://orcid.org/0009-0004-4165-1691
Xiaodong WangHepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, Zhejiang, China.
Ya ZhangHepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, Zhejiang, China.
Yongping ChenHepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, Zhejiang, China. cyp@wmu.edu.cn.ORCID http://orcid.org/0000-0002-4471-3083
Dazhi ChenSchool of Clinical Medicine, The First People's Hospital of Lin'an Distract, Hangzhou, Lin'an People's Hospital Affiliated to Hangzhou Medical College, Hangzhou Medical College, Hangzhou, Zhejiang, China. dazhichen@126.com.ORCID http://orcid.org/0000-0001-8895-8536
Funding
National Natural Science Foundation of China (National Science Foundation of China) 82070593Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LTGY24H030010Science and Technology Department of Zhejiang Province 2022C03125Science and Technology Department of Zhejiang Province 2025C02135
6 · The paper itself
Abstract
Nicotine accumulation in the intestine is associated with an exacerbation of metabolic dysfunction-associated steatohepatitis (MASH), but the underlying mechanisms remain enigmatic. We investigated how nicotine impacted intestinal microbiota composition and barrier function in MASH. Our study revealed significant intestinal microbiota dysbiosis and upregulated hypoxia-inducible factor 1-alpha (HIF-1α) levels in nicotine-exposed MASH mice. HIF-1α knockdown worsened intestinal barrier dysfunction in nicotine-exposed MASH mice. This exacerbation resulted from the suppression of MEK/ERK signaling pathway phosphorylation in HIF-1α-deficient mice. Lactobacillus rhamnosus GG supernatant can alleviate hepatic injury in nicotine-exposed MASH mice; however, this protective effect was abolished in the absence of HIF-1α. Taken together, this study reveals a critical pathologic role of nicotine in exacerbating MASH through intestinal microbiota disruption and barrier dysfunction, which is associated with the downregulation of HIF-1α in the intestine. It also suggests exogenous probiotic supplementation as a potential therapeutic strategy for mitigating nicotine-induced MASH progression.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Nicotine exacerbates MASH via inducing intestinal dysbiosis and barrier dysfunction. · full record | Socratic