Evidence map›Paper›PMID 41351269›Full record

ArticlePhysiological reports2025

The role of bioactive lipids and eicosanoid metabolites in acute exercise in adults: Insights into human cardiorespiratory fitness.

Mythri Ambatipudi, Athar Roshandelpoor, J Sawalla Guseh, Leah B Kosyakovsky, Mona Alotaibi, Susan Cheng, Mohit Jain, Gregory D Lewis, Jennifer E Ho

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mythri AmbatipudiCardioVascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0002-7460-7492
Athar RoshandelpoorCardioVascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
J Sawalla GusehCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Leah B KosyakovskyCardioVascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Mona AlotaibiDivision of Pulmonary and Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California, USA.
Susan ChengDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Mohit JainDepartment of Medicine and Department of Pharmacology, University of California San Diego, La Jolla, California, USA.
Gregory D LewisCardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jennifer E HoCardioVascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0002-7987-4768

Funding

Endothelial Cell Health Across the Spectrum of Cardiometabolic DiseaseR01HL168889 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Naomi Miriam Hamburg, Jennifer E Ho · 2023 to 2026
$3.1M
Long-Term Endothelial Effects of COVID-19 in ObesityR01HL160003 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HAMBURG, NAOMI MIRIAM, HO, JENNIFER E · 2022 to 2025
$2.8M
Mentoring in Patient-Oriented and Translational HFpEF ResearchK24HL153669 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jennifer E Ho · 2020 to 2026
$744k
HHS | National Institutes of Health (NIH) R01-HL140224NHLBI NIH HHS K24 HL153669NHLBI NIH HHS R01 HL160003NHLBI NIH HHS R01 HL168889
6 · The paper itself

Abstract

The molecular mechanisms underlying the salutary effects of exercise remain incompletely understood. Exerkines are signaling molecules with autocrine, paracrine, or endocrine effects released in response to exercise. Specific eicosanoids, small bioactive lipids, act as exerkines. Using a mass spectrometry-based platform, we assayed eicosanoids and related metabolites at rest and peak exercise in individuals undergoing cardiopulmonary exercise testing (CPET). We examined changes in metabolites with exercise and associations with cardiorespiratory fitness measured by peak VO

Indexed as

Cardiorespiratory FitnessEicosanoidsExerciseLipid MetabolismAdultAgedExercise TestFemaleHumansMaleMiddle AgedOxygen ConsumptionEicosanoidsacute exercisecardiorespiratory fitnessCPETeicosanoidsmetabolomicspeak VO2

Identifiers

PMID41351269
PMCPMC12680789

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.