ArticleEuropean journal of neurology2025
The Association Between Detailed Obesity Measurements and Peripheral Neuropathy in Persons With Diabetes.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Close relationship between β2-microglobulin and type 2 diabetes-associated peripheral neuropathy.Journal of diabetes investigation · 2026Article
- Body mass index and peripheral neuropathy across the glucose tolerance spectrum in Japanese adults.Journal of diabetes investigation · 2026Article
- Pain Modulation and Central Sensitization in Painful Diabetic Peripheral Neuropathy: Updated Narrative Review and Future Directions.Journal of diabetes · 2026Review
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Authors and funding
6 authors.
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Abstract
backgroundObesity increases the risk of diabetic peripheral neuropathy (DPN). However, past studies have typically assessed obesity using anthropometric measurements. Our primary aim determined associations between detailed obesity measurements, DPN, and painful DPN (pDPN). Our secondary aim compared the discriminatory capabilities of these measurements.
methodsWe performed a cross-sectional study of persons with diabetes. Obesity was assessed using anthropometrics, bioelectrical impedance (BIA), abdominal MRIs (aMRI), and/or dual x-ray absorptiometry (DEXA). Obesity measurements were categorized as measuring general, central, or peripheral obesity, or the central-peripheral obesity ratio. DPN was defined as Michigan Neuropathy Screening Instrument questionnaire ≥ 4. Within this group, pDPN was defined as bilateral foot pain in the prior 3 months. Areas under receiver operating characteristic curves (AUC) determined discriminatory capabilities of obesity measurements for DPN, stratified by sex.
resultsWe identified 7090 persons with diabetes that completed DPN assessments (mean age: 58.4, 39.6% female), of which 100.0% completed anthropometrics, 98.4% completed BIA, 3.9% completed aMRI, and 2.3% completed DEXA. 1271 (17.9%) had DPN with 28.1% experiencing pDPN. Logistic regression revealed 13/13 anthropometric, 27/29 BIA, 21/34 DEXA, and 8/14 aMRI measurements associated with DPN, but none associated with pDPN. For males, median AUCs for DPN were similar regardless of location (central: 0.88, 0.89, general: 0.89, peripheral: 0.88, central-peripheral ratio: 0.87), whereas for females, central obesity (0.92) had the largest AUC for DPN, followed by general (0.88), peripheral (0.84), and central-peripheral obesity ratio (0.78).
conclusionsObesity is associated with DPN, but not pDPN. For males, obesity distribution did not differentially discriminate DPN, whereas for females, central obesity best discriminated DPN.
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