Evidence map›Paper›PMID 41351717›Full record

SynthesisGeroScience2026

The effect of anthocyanins and anthocyanin-rich foods on cognitive function: a meta-analysis of randomized controlled trials.

Agnieszka Micek, Justyna Godos, Francesca Giampieri, Maurizio Battino, José L Quiles, Daniele Del Rio, Pedro Mena, Giuseppe Caruso, Evelyn Frias-Toral, Irma Domínguez Azpíroz and 8 more

Erratum issuedAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Agnieszka MicekStatistical Laboratory, Faculty of Health Sciences, Jagiellonian University Medical College, 31-501, Cracow, Poland.
Justyna GodosDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Francesca GiampieriDepartment of Clinical Sciences, Università Politecnica Delle Marche, 60131, Ancona, Italy.
Maurizio BattinoDepartment of Clinical Sciences, Università Politecnica Delle Marche, 60131, Ancona, Italy.
José L QuilesDepartment of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Centre, University of Granada, Avda. del Conocimiento S.N., 18100, Armilla, Spain.
Daniele Del RioHuman Nutrition Unit, Department of Food and Drug, University of Parma, 43125, Parma, Italy.
Pedro MenaHuman Nutrition Unit, Department of Food and Drug, University of Parma, 43125, Parma, Italy.
Giuseppe CarusoDepartmental Faculty of Medicine, UniCamillus-Saint Camillus International University of Health and Medical Sciences, Rome, Italy. giuseppe.caruso@unicamillus.org.ORCID http://orcid.org/0000-0003-1571-5327
Evelyn Frias-ToralSchool of Medicine, Universidad Espíritu Santo, Samborondón, 0901952, Ecuador.
Irma Domínguez AzpírozResearch Group On Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres 21, 39011, Santander, Spain.
Jianbo XiaoDepartment of Analytical Chemistry and Food Science, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, 32004, Ourense, Spain.
Nicola VeroneseSaint Camillus International, University of Health Sciences, Rome, Italy.
Mario SiervoCurtin-Chulalongkorn Collaborative Centre for Nutrition and Food Research and Education, Curtin University, Perth, WA, Australia.
David VauzourNorwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
Zoltan UngvariVascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Fabio GalvanoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Giuseppe GrossoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
International Network for Evidence on Phytochemicals and Biotics for Human Health

Funding

National Science Centre No. 2023/07/X/NZ7/01127
6 · The paper itself

Abstract

The rising prevalence of cognitive disorders highlights the urgent need for effective prevention strategies and therapeutic interventions. While adherence to a balanced diet has been associated with a reduced risk of cognitive decline, emerging evidence underscores the potential role of plant-derived bioactive compounds, such as (poly)phenols, with anthocyanins receiving increasing attention. This meta-analysis aimed to evaluate the effect of anthocyanin-rich interventions on cognitive performance. A systematic search of randomized controlled trials (RCTs) assessing the effects of anthocyanin supplementation and cognitive outcomes identified 59 eligible studies. Overall, anthocyanin intervention significantly improved global cognition (standardized mean difference (SMD) = 0.46, 95% CI = 0.30 to 0.63, I

Indexed as

AnthocyaninsCognitionCognitive DysfunctionCognitive EnhancementDietary SupplementsHumansRandomized Controlled Trials as TopicAnthocyaninsAnthocyaninsBrainCognitionFlavonoidsMemoryPolyphenols

Identifiers

PMID41351717
PMCPMC13601464

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.