Evidence map›Paper›PMID 41352163›Full record

ArticleEnvironment international2026

The development of the Human Health Exposure Analysis Resource (HHEAR) Data Repository for environmental epidemiology research.

Jeanette A Stingone, Sofia Bengoa, Carolina Valle, James Masters, Tyrone Cadenhead, Alona Rabin, Paulo Pinheiro, Moira Bixby, Matthew Mazzella, Emily Spear and 6 more

Abstract read
In one paragraph

Article in Environment international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jeanette A StingoneDepartment of Epidemiology, Columbia University Mailman School of Public Health, 722 W 168 Street, Room 1608, New York, NY 10032, United States. Electronic address: j.stingone@columbia.edu.
Sofia BengoaDepartment of Epidemiology and Biostatistics, CUNY Graduate School of Public Health and Health Policy, 55 West 125th Street, New York, NY 10027, United States. Electronic address: sofia.bengoa@sph.cuny.edu.
Carolina ValleDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 17 E 102 St, New York, NY 10029, United States. Electronic address: carolina.valle@mssm.edu.
James MastersScientific Computing and Data, Icahn School of Medicine at Mount Sinai, 150 E 42nd St, New York, NY 10017, United States. Electronic address: james.masters@mssm.edu.
Tyrone CadenheadScientific Computing and Data, Icahn School of Medicine at Mount Sinai, 150 E 42nd St, New York, NY 10017, United States. Electronic address: tyrone.cadenhead@mssm.edu.
Alona RabinScientific Computing and Data, Icahn School of Medicine at Mount Sinai, 150 E 42nd St, New York, NY 10017, United States. Electronic address: Alona.Rabin@mountsinai.org.
Paulo PinheiroInstituto Piaget de Almada, Avenida Jorge Peixinho, n.° 30 Quinta da Arreinela, 2805-059 Almada, Setúbal, Portugal. Electronic address: paulo.pinheiro@ipiaget.pt.
Moira BixbyDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 17 E 102 St, New York, NY 10029, United States. Electronic address: moira.bixby@mssm.edu.
Matthew MazzellaDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 17 E 102 St, New York, NY 10029, United States. Electronic address: matthew.mazzella@mssm.edu.
Emily SpearDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 17 E 102 St, New York, NY 10029, United States. Electronic address: emily.spear@mssm.edu.
Henrique SantosTetherless World Constellation, Rensselaer Polytechnic Institute, Winslow Building, 110 8th Street, Troy, NY 12180, United States. Electronic address: oliveh@rpi.edu.
Chris GenningsDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 17 E 102 St, New York, NY 10029, United States. Electronic address: chris.gennings@mssm.edu.
Deborah McGuinnessTetherless World Constellation, Rensselaer Polytechnic Institute, Winslow Building, 110 8th Street, Troy, NY 12180, United States. Electronic address: dlm@cs.rpi.edu.
Patricia KovatchScientific Computing and Data, Icahn School of Medicine at Mount Sinai, 150 E 42nd St, New York, NY 10017, United States; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, Icahn (East) Building 1425 Madison Ave, New York, NY 10029, United States. Electronic address: patricia.kovatch@mssm.edu.
Nancy MervishDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 17 E 102 St, New York, NY 10029, United States. Electronic address: nancy.mervish@mssm.edu.
Susan L TeitelbaumDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, 17 E 102 St, New York, NY 10029, United States. Electronic address: susan.teitelbaum@mssm.edu.

Funding

Statistical Services and Methods Development ResourceU2CES026555 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GENNINGS, CHRIS · 2015 to 2025
$26.4M
NIEHS NIH HHS U2C ES026555
6 · The paper itself

Abstract

Implementation of the exposome paradigm is a critical aspect of the next generation of environmental health research studies. To spur exposomics research, the U.S.-based Human Health Exposure Analysis Resource (HHEAR) provided scientific investigators access to both laboratory and statistical analyses aimed at incorporating and expanding the breadth of biological markers of environmental exposures within their research. To extend the benefits of this program to the broader scientific community, the HHEAR Data Center established a public data repository to facilitate pooling and sharing of data generated by the HHEAR program. All HHEAR investigators deposited epidemiologic data on study participants, to accompany the biomarkers of exposure generated by the HHEAR laboratories. The latest semantic technologies are used to efficiently conduct data standardization across studies and promote data sharing by aligning the repository with the FAIR (Findable, Accessible, Interoperable, Reusable) data principles. This includes standardizing individual study data to a common ontology and representing data within a knowledge graph. A clear user interface enables search, construction, and download of customized datasets and maintenance of provenance through use of digital object identifiers. The repository will eventually contain information from 35,989 individuals across 55 environmental health studies, including data on biomarkers of environmental exposures, sociodemographics, health outcomes, and physical and mental assessments. All data are freely downloadable for reuse after a brief application for data access. Designed to support cutting-edge research and education, the HHEAR Data Repository provides a rich, harmonized resource of exposure biomarkers and corresponding health data from diverse study populations.

Indexed as

Databases, FactualEnvironmental ExposureEnvironmental HealthExposomeBiomarkersHumansUnited StatesBiomarkersBiomarkersData repositoryEnvironmental healthExposomeFAIR

Identifiers

PMID41352163
PMCPMC12857295

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.