Evidence map›Paper›PMID 41353172›Full record

ArticleCell death discovery2025

Niacin inhibits vascular calcification via modulating of SIRT1/SIRT6 signaling pathway.

Chao-Hua Kong, Li-da Wu, Yue Sun, Xiao-Min Jiang, Yi Shi, Feng Wang, Dong-Chen Wang, Yue Gu, Wen-Ying Zhou, Jin-Que Luo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chao-Hua Kong *Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Li-da Wu *Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yue Sun *Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xiao-Min JiangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yi ShiDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Feng WangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Dong-Chen WangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yue GuDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Wen-Ying ZhouDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Jin-Que LuoHunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, "The 14th Five-Year Plan" Application Characteristic Discipline of Hunan Province (Pharmaceutical Science), College of Pharmacy, Changsha Medical University, Changsha, Hunan, China.
Shao-Liang ChenDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. chmengx@126.com.ORCID http://orcid.org/0009-0000-2252-6140
Yue-Lin ChaoDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. chaoyuelincchy@163.com.

Funding

Nanjing Medical University (NMU) JX218GSP20240501002National Natural Science Foundation of China (National Science Foundation of China) No.82170350
6 · The paper itself

Abstract

Vascular calcification (VC) is a common pathological state that often accompanies calcium-phosphorus metabolism disorder and chronic kidney diseases (CKDs). Vascular smooth muscle cell (VSMC) has been widely acknowledged as one of the main cell types involved in this process. Niacin, a lipid-lowering reagent, has been demonstrated to be beneficial in atherosclerotic disease, but its role in vascular calcification remains unexplored. Restricted cubic spline (RCS) analysis of clinical datasets revealed an inverse correlation between dietary niacin intake and abdominal aortic calcification (AAC). Our data showed that niacin treatment remarkably reduced VSMC osteogenic differentiation. Moreover, niacin treatment alleviated CKD and vitamin D

Identifiers

PMID41353172
PMCPMC12827405

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.