SynthesisBMC cancer2025
Evidence-based prescription: optimal exercise type and dose for pain management in breast cancer survivors-a systematic review and dose-response network meta-analysis.
Synthesis in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Less is more? Questioning the walking dose in the WISE trial.Breast (Edinburgh, Scotland) · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCancer-related pain resulting from tumors and long-term treatments significantly impacts the quality of life in breast cancer survivors. While exercise has been proven to alleviate pain, a standardized prescription is still lacking. This study explores the efficacy and optimal dosage of various exercise modalities for pain relief in breast cancer survivors, aiming to guide clinical practice and improve long-term outcomes.
methodsBayesian network and dose-response meta-analyses with a random-effects model were used to assess the effect of exercise on pain in breast cancer survivors. The evidence quality was evaluated using the Confidence in Network Meta-Analysis (CINeMA) web application.
resultsA total of 25 studies involving 1,899 patients were included. An inverted U-shaped dose-response relationship was observed between overall exercise and pain, with an effective dose range of 0-1300 metabolic equivalent of task minutes per week (MET-min/week) and maximum effect at 780 MET-min/week (SMD = 1.15, 95% CrI: 0.7, 1.61). When stratified by exercise type, aerobic exercise (0-140 min/week), resistance training (0-140 min/week), combined aerobic and resistance training (0-290 min/week), yoga (0-220 min/week), and walking (0-55 min/week) all demonstrated significant associations with pain reduction. The comprehensive ranking suggested that 170 min of combined aerobic and resistance training per week (SMD = 1.37, 95% CrI: 0.73, 2.07) may be the most effective type and dose for pain alleviation.
conclusionsCombined aerobic and resistance training are recommended as the primary option for pain relief in breast cancer survivors, based on effect sizes, sample sizes, 95% CrI precision. However, due to the very low and low quality of evidence for several exercise modalities, high-quality randomized controlled trials are needed to validate the efficacy of the recommended dose ranges.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.