Evidence map›Paper›PMID 41353197›Full record

ReviewBiology direct2025

Autophagy and mitophagy in dermatological disease: a comprehensive review from molecular pathways to therapeutic frontiers.

Luca D'Ambrosio, Maria Elisabetta Greco, Maurizio Forte, Daniele Vecchio, Sonia Schiavon, Flavio Di Nonno, Shazia Tahir, Vittorio Picchio, Claudia Cozzolino, Gianmarco Sarto and 12 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Luca D'Ambrosio *Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli (IS), Italy.
Maria Elisabetta Greco *Dermatology Clinic, Department of Medical and Cardiovascular Sciences, University of Rome, "Sapienza", Rome, Italy.
Maurizio ForteDepartment of Angiocardioneurology, IRCCS Neuromed, Pozzilli (IS), Italy.
Daniele VecchioDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Sonia SchiavonDepartment of Angiocardioneurology, IRCCS Neuromed, Pozzilli (IS), Italy.
Flavio Di NonnoDepartment of Angiocardioneurology, IRCCS Neuromed, Pozzilli (IS), Italy.
Shazia TahirPrecision Medicine in Medical, Surgical and Critical Areas, University of Palermo, Palermo, Italy.
Vittorio PicchioDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Claudia CozzolinoDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Gianmarco SartoICOT Istituto Marco Pasquali, Via Franco Faggiana 1668, Latina, 04100, Italy.
Marco BernardiDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Luigi SpadaforaDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Beatrice SimeoneICOT Istituto Marco Pasquali, Via Franco Faggiana 1668, Latina, 04100, Italy.
Mattia VinciguerraLancashire Cardiac Centre, Blackpool Victoria Hospital, Blackpool, UK.
Sebastiano SciarrettaDepartment of Angiocardioneurology, IRCCS Neuromed, Pozzilli (IS), Italy.
Giacomo FratiDepartment of Angiocardioneurology, IRCCS Neuromed, Pozzilli (IS), Italy.
Ernesto GrecoDepartment of Health and Life Sciences, European University of Rome, Rome, Italy.
Concetta PotenzaDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Ilaria ProiettiDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Jacopo MorroniNeurology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Elisa Dietrich *Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Leonardo Schirone *Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli (IS), Italy. leonardo.schirone@unier.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy - the cell's built-in recycling and quality-control programme - touches every layer of cutaneous biology. In keratinocytes it sculpts the cornified envelope; in melanocytes it balances pigment synthesis and oxidative stress; in immune and appendageal cells it fine-tunes defence, repair and hair-follicle cycling. When this choreography falters, skin disorders emerge. This review journeys from basic mechanisms (ULK1 signalling, Beclin-1/VPS34 nucleation, LC3B lipidation, selective mitophagy) to their fingerprints in health and disease. We dissect how autophagy malfunctions drive psoriasis hyper-proliferation, atopic-dermatitis barrier leakiness, vitiligo depigmentation and the metabolic rewiring of melanoma. Non-melanoma cancers, infectious dermatoses, wound repair, ageing and photo-damage are mapped onto the same autophagic atlas. Therapeutically, the pathway is a double-edged sword. mTOR or caloric-restriction mimetics jump-start a protective flux; chloroquine derivatives and ULK1 blockers clip tumour survival circuits; cannabinoids, photodynamic therapy and immune-checkpoint combinations exploit context-specific toggling between induction and brake. Emerging biomarkers (LC3B-II, p62, AMBRA1) promise patient-stratified interventions. By weaving together molecular detail, pre-clinical insight and clinical translation, we show why autophagy is no longer a backstage process but a star player in dermatology - and how targeting its switches could reshape future treatment algorithms.

Indexed as

AutophagyMitophagySkin DiseasesAnimalsHumansSignal TransductionAutophagyDermatological diseaseImmunodermatologyMitophagySkin disordersSkin homeostasis

Identifiers

PMID41353197
PMCPMC12781533

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.