ArticleParasites & vectors2025
Efficacy of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) and Credelio™ (lotilaner) chewable tablets in the prevention of Borrelia burgdorferi transmission from infected Ixodes scapularis in dogs.
Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Comparative speed of kill of induced Ixodes scapularis infestations following treatment of dogs with endectocides containing either sarolaner (Simparica Trio™), afoxolaner (NexGardParasites & vectors · 2026Article
- Efficacy of Credelio Quattro™ chewable tablets containing lotilaner, moxidectin, pyrantel, and praziquantel against Ctenocephalides felis and Rhipicephalus sanguineus infestations on dogs.Parasites & vectors · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBorrelia burgdorferi, the causative agent of Lyme disease, is a zoonotic vector-borne pathogen transmitted by various Ixodes tick species. Lyme disease, while commonly asymptomatic, can induce fever and intermittent lameness in dogs. Highly effective acaricidal products with a rapid onset of action along with prompt removal of attached ticks are important aspects of successful Lyme disease prevention strategies.
methodsTwo studies were conducted with a total of 30 dogs each. Dogs were randomized to receive a control sham dose, Credelio Quattro, or Credelio. Treatment was administered on Day 0 in a fed state. On Day 28, all dogs were experimentally infested with wild-caught adult Ixodes scapularis. Blood samples for B. burgdorferi antibody analysis utilizing the SNAP 4Dx Plus and Lyme Quant C
resultsAll control dogs demonstrated adequate I. scapularis infestation rates on Day 33 in both studies. In Study 2, on Day 27, one control dog tested positive for B. burgdorferi on the Lyme Quant C
conclusionsThe laboratory studies described herein confirm that a single dose of lotilaner, at the minimum effective dosage of 20 mg/kg, administered as Credelio Quattro, in combination with moxidectin, praziquantel, and pyrantel or Credelio, is effective for the prevention of transmission of B. burgdorferi from infected I. scapularis for a full month in dogs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.