Evidence map›Paper›PMID 41354326›Full record

ArticleJournal of lipid research2026

Long-chain polyunsaturated fatty acid lipid and oxylipin alterations in postoperative delirium after cardiac surgery.

Kwame Wiredu, Pruthvi Gowda, James Rhee, Ariel Mueller, Christopher Simon, Occam Kelly Graves, Jason Zhensheng Qu, Matthew Spite, Tina B McKay, Oluwaseun Akeju

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kwame WireduMass General Brigham Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA.
Pruthvi GowdaDepartment of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
James RheeMass General Brigham Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA.
Ariel MuellerMass General Brigham Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA; Mass General Brigham Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA, USA.
Christopher SimonMass General Brigham Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA.
Occam Kelly GravesMass General Brigham Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA.
Jason Zhensheng QuMass General Brigham Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA.
Matthew SpiteMass General Brigham Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA, USA.
Tina B McKayMass General Brigham Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA. Electronic address: tmckay@mgh.harvard.edu.
Oluwaseun AkejuMass General Brigham Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, USA; Mass General Brigham Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA, USA.

Funding

Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS II)R01AG083777 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JOHNSON-AKEJU, OLUWASEUN · 2024 to 2025
$7.3M
Investigation of a Novel Biomarker of Postoperative DeliriumR21AG073750 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JOHNSON-AKEJU, OLUWASEUN, MCKAY, TINA · 2022 to 2023
$462k
NIA NIH HHS R01 AG083777NIA NIH HHS R21 AG073750
6 · The paper itself

Abstract

Lipids play a crucial role in signaling, membrane dynamics, and inflammatory regulation, yet their involvement in postoperative delirium pathogenesis remains unclear. This study examined serum lipidomic alterations in postoperative delirium and assessed the effects of dexmedetomidine treatment on these changes. Lipidomic profiling was conducted at baseline and postoperative day 1 in two independent cohorts of cardiac surgery patients. Mass spectrometry-based shotgun lipidomics and targeted lipid analyses were used to assess lipidomes and oxylipins, respectively. Cardiac surgery was associated with decreased serum lysophospholipids. Postoperative delirium was associated with increased long-chain polyunsaturated fatty acid phospholipids, particularly phosphatidylethanolamines, and elevated oxylipins. Dexmedetomidine, a potential delirium-mitigating medication, reduced long-chain polyunsaturated fatty acid phospholipids. These findings highlight lipid modulation as a potential target for postoperative delirium prevention.

Indexed as

Cardiac Surgical ProceduresDeliriumFatty Acids, UnsaturatedOxylipinsPostoperative ComplicationsAgedFemaleHumansLipidomicsMaleMiddle AgedFatty Acids, UnsaturatedOxylipinsAlzheimer's diseasecognitive dysfunctionConfusion Assessment Methoddementiadexmedetomidinehyperlipidemialipidomicoxidative stressoxylipin

Identifiers

PMID41354326
PMCPMC12796732

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.