Evidence map›Paper›PMID 41354622›Full record

Trial reportThe clinical respiratory journal2025

Endothelial-Derived Extracellular Vesicles During Exercise in COPD Patients.

Samuel C Okpechi, Dorota Wyczechowska, Bennett DeBoisblanc, Jessica L Johnson, Mohamed A Ghonim, Natalie Bauer, Hamid A Boulares, Matthew R Lammi

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The clinical respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samuel C OkpechiStanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Dorota WyczechowskaStanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Bennett DeBoisblancSection of Pulmonary/Critical Care and Allergy/Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Jessica L JohnsonComprehensive Pulmonary Hypertension Center, University Medical Center, New Orleans, Louisiana, USA.
Mohamed A GhonimStanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Natalie BauerDepartment of Pharmacology and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, Alabama, USA.
Hamid A BoularesStanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Matthew R LammiSection of Pulmonary/Critical Care and Allergy/Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Funding

Louisiana Clinical and Translational Sciences Center U54-GM-104940NIGMS NIH HHS 1-P306-M-206932-01A1
6 · The paper itself

Abstract

introductionThere are no treatments directly targeting the pulmonary vasculature in chronic obstructive pulmonary disease (COPD), and further characterization of the underlying endothelial cell (EC) abnormalities could be helpful in drug development.

methodsWe investigated the influence of exercise and the prostacyclin analog iloprost on extracellular vesicles derived from ECs (eEVs) in 15 moderate-severe COPD patients who were enrolled in a randomized, placebo-controlled crossover trial of iloprost.

resultsActive smokers had a profile consistent with inflammatory-derived EVs, while exacerbation-prone COPD subjects had a profile consistent with apoptosis-derived eEVs. There were no significant effects of iloprost on eEV levels. However, there was a significant increase in CD144+ and CD31+/CD144+ EVs 1 h after exercise.

conclusionsEndothelial-derived EV profiles differed based on smoking and exacerbation history. Iloprost did not affect eEV levels, although maximal exercise induced a delayed increase in a subset of eEVs, possibly through shear stress.

Indexed as

Endothelial CellsExerciseExtracellular VesiclesIloprostPulmonary Disease, Chronic ObstructiveAgedCross-Over StudiesEndothelium, VascularFemaleHumansMaleMiddle AgedSmokingIloprost

Identifiers

PMID41354622
PMCPMC12682462

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.