ArticleNPJ Parkinson's disease2025
Local field potentials survey to guide DBS programming in Parkinson's disease: a clinical-neurophysiological longitudinal study.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Inconsistent subthalamic local field potential beta activity amid in- and antiphasic neuronal bursts.NPJ Parkinson's disease · 2026Article
- Reply to: Bridging predictive algorithms and clinical practice in DBS contact selection.NPJ Parkinson's disease · 2026Article
- Deep Brain Stimulation after Subthalamic Focused Ultrasound for Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Long-lasting concordance between imaging-guided and clinical-based STN-DBS programming enhances motor and axial outcomes in Parkinson's disease: A 3-year single-center study.Journal of Parkinson's disease · 2026Article
- Entrainment of cortical gamma oscillations predicts improved bradykinesia and dyskinesia in Parkinson's disease.medRxiv : the preprint server for health sciences · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep Brain Stimulation (DBS) programming in Parkinson's disease relies on clinical evaluation, yet beta-band activity in local field potentials (LFPs) may offer objective guidance. We evaluated LFP-guided contact selection against clinical programming (CP) at initial monopolar review and long-term follow-up. Bipolar LFPs were recorded in patients with sensing-enabled DBS systems, where central levels were clinically chosen. Three methods based on beta peak amplitude were tested: Broad-Bipolar (non-adjacent rings), Narrow-Bipolar (contiguous rings), and Segment-Bipolar (horizontal segments). Performance was assessed using correlation, agreement, and selection similarity with CP and compared to random selection. Narrow-Bipolar showed the strongest correlation and agreement with CP at both timepoints, outperforming other methods and random selection. It showed the greatest selection stability over time and the highest prediction. Its performance was comparable to imaging-guided programming and did not differ between STN and GPi. These results support Narrow-Bipolar as a valid, easy-to-perform beta-based method for guiding DBS programming.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.