ReviewCommunications biology2025
Catabolic rewiring in cancer impacts dietary interventions.
Review in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Dual-tracer PSMA/FDG PET/CT for lesion detection and risk stratification in biochemical recurrence with negative conventional imaging.European journal of nuclear medicine and molecular imaging · 2026Article
- Management of advanced HR-positive breast cancer using metabolically supported chemotherapy and repurposed drugs: a case report.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumors exhibit metabolic fuel requirements resembling those of embryonic and other highly proliferative tissues, a similarity that can be exploited to combat neoplasia. However, several challenges limit the efficacy of dietary modifications in cancer therapy. This review explores how cancer cells acquire and catabolize macromolecules to harness energy and assesses the feasibility of influencing these pathways through dietary changes. Although dietary interventions modulate the energetic substrate supply to tumors only to a limited extent, they offer significant ancillary benefits by imposing hormonal states that burden cancer metabolism, enhancing immune responses, and reducing inflammation. Integrating dietary considerations into the standard of care for cancer patients represents a promising adjunct to traditional treatments, despite their dampened impact on nutrient availability for tumor energy metabolism.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.