ArticleJournal of orthopaedic surgery and research2025
Sarcopenia index is a superior prognostic marker to creatinine-cystatin C ratio in older adults with hip fracture.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSarcopenia is prevalent in older adults with hip fracture and is associated with poor postoperative outcomes. This study aimed to evaluate the prognostic value of sarcopenia index (SI) and creatinine-cystatin C ratio (CCR) in predicting postoperative mortality in older patients with hip fracture.
methodsA retrospective study was conducted on 485 older adults (aged ≥ 65 years) with hip fracture treated at Zhongda Hospital between January 2018 and December 2022. SI and CCR were calculated using serum creatinine and cystatin C. The primary outcome was all-cause mortality at 1, 3, and 12 months.
resultsAmong the 485 patients, 46 (9.5%) died within one year. Both SI and CCR presented positive and significant correlations with muscle mass and density, while SI showed a stronger association than CCR. Propensity score matching confirmed that patients in the lowest SI tercile had significantly higher 1-month, 3-month, and 12-month mortality compared to those in the highest ones (7.2% vs. 0%, 10.8% vs. 2.4%, and 19.3% vs. 8.4%). ROC analyses indicated that SI had a moderate predictive accuracy for mortality, with AUCs of 0.745 (95% CI 0.628-0.862), 0.684 (95% CI 0.589-0.779), and 0.617 (95% CI 0.536-0.697) for 1-month, 3-month, and 12-month mortality, respectively. In addition, SI showed a higher predictive accuracy for postoperative mortality in the early period and in females.
conclusionSI is a reliable and useful marker for predicting short-term mortality in older adults with hip fracture, which can serve as a valuable tool for early diagnosis and intervention in the future.
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