ArticleBMC pediatrics2025
Implications of pubertal stage in cardiometabolic risk factors in obese adolescents: a network analysis.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDespite the existence of numerous studies describing the early stages of sexual maturation in overweight children, there is still a gap in understanding the consequences of obesity at each level of pubertal development and its association with cardiometabolic diseases. Network analysis thus proves to be a promising approach for understanding the complexity of obesity in adolescence.
objectiveThis study aimed to analyze the associations of cardiometabolic risk factors at the expense of the pubertal stage in overweight adolescents.
methodsThis cross-sectional study analyzed 97 adolescents (54.6% females, mean age 12.87 ± 2.48 years old). Sociodemographic information, anthropometric, body composition, and biochemical data [fasting glucose, cholesterol, high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), and triglycerides] were collected. Adolescents were classified according to pubertal stage (PS, n = 59) or postpubertal stage (PPS, n = 38). The study employed an unpaired t test to compare the variables based on pubertal stage, with a significance level of 5%. In addition, Bayesian network analysis was used to investigate the associations between cardiometabolic risk factors and puberty.
resultsThe analysis revealed the indicator of expected influence centrality, highlighting the network's key factors. The network configuration had a more significant influence on the fat mass (FM) (1.863), HDL-c (-1.137), and fat-free mass (FFM) (1.392) parameters in the PS group and on the PPS - HDL-c (-1.389), lean mass (LM) (1.269), and FFM (1.220) parameters. The analysis also revealed the indicator of expected influence centrality, highlighting the network's key factors. When the stages in the PSS group were compared, the values of body mass, height, body mass index, abdominal circumference, FFM, LM, FM, and visceral fat were measured.
conclusionThese findings suggest the need for tailored strategies and programs to prevent excess weight and improve cardiometabolic health in adolescents, regardless of pubertal stage, to mitigate the long-term damage caused by obesity.
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