ArticlePsychopharmacology2026
Adolescent binge drinking causes sex-specific deficits in behavioral reactivity, endocrine recovery from stress and altered expression of hypothalamic KCC2 in males.
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
rationaleBinge drinking during adolescence is associated with a higher risk of developing Alcohol Use Disorders and impaired stress reactivity in adulthood. The hypothalamic-pituitary-adrenal axis matures during adolescence and is under strict GABAergic control. Yet, how early binge drinking alters GABAergic signaling in this region, and whether these changes contribute to later-life disruptions in stress reactivity, remain unknown.
objectivesOur goal with these set of experiments was to test the hypothesis that adolescent binge drinking would impair maturation of GABAergic signaling in the paraventricular nucleus (PVN) and lead to aberrant behavioral and neuroendocrine stress reactivity.
methodsAdolescent male and female C57BL/6J mice were given access to 20% ethanol or tap water under Drinking in the Dark-Multiple Scheduled Access paradigm from PD28 to PD42 and went through abstinence until adulthood. At adulthood (PD60+), the behavioral and endocrine response to two stressors, forced swim stress and social defeat stress, were evaluated.
resultsOnly females with a history of adolescent drinking showed abnormal behavioral reactivity to stress, with increased immobility in the forced swim stressor task. Females with a history of adolescent binge drinking displayed a hypo-corticosterone response after social stress and males showed delayed negative feedback to the forced swim stressor. PVN-enriched tissue from these mice showed no changes in transcription of Gabrg2, but males showed a significant increase in expression of Slc12a5, which encodes for the chloride potassium co-transporter, KCC2. These males showed no change in KCC2 protein when evaluated by immunohistochemistry.
conclusionsTaken together, these data show that adolescent binge drinking in pair-housed mice is associated with male-specific potential vulnerability in hypothalamic inhibitory signaling and disrupted adult stress reactivity in a sex- and stressor- dependent manner.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.