Evidence map›Paper›PMID 41355493›Full record

ArticleEpigenetics2025

Changes in nuclear and mitochondrial DNA methylation in cow blood associated with age and disease.

Lotfi Bouzeraa, Camila Bruna de Lima, Helene Martin, Jessica C S Marques, Ronaldo Cerri, Mohamed Oudihat, Marc-Andre Sirard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lotfi BouzeraaDepartment of Animal Sciences, Faculty of Agricultural and Food Sciences, Laval University, Québec, QC, Canada.ORCID 0009-0001-4770-369X
Camila Bruna de LimaDepartment of Animal Sciences, Faculty of Agricultural and Food Sciences, Laval University, Québec, QC, Canada.
Helene MartinDepartment of Animal Sciences, Faculty of Agricultural and Food Sciences, Laval University, Québec, QC, Canada.
Jessica C S MarquesFaculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada.
Ronaldo CerriFaculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada.
Mohamed OudihatDepartment of Animal Sciences, Faculty of Agricultural and Food Sciences, Laval University, Québec, QC, Canada.
Marc-Andre SirardDepartment of Animal Sciences, Faculty of Agricultural and Food Sciences, Laval University, Québec, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation is among the most promising biomarkers for age prediction, enabling the development of epigenetic clocks that correlate methylation profiles with chronological age. In this study, we investigated the relationship between ageing and disease susceptibility, focusing on both nuclear and mitochondrial DNA methylation in dairy cows. Genome-wide DNA methylation profiling was performed using enzymatic methyl-seq, covering 53 million CpG sites. The dataset included 96 cows with different phenotypes, sampled cross-sectionally and ranging from 2 to 9 years of age. We applied elastic net regression to identify the most predictive CpG sites for age estimation, achieving a mean absolute error of 111 days with a strong correlation to chronological age

Indexed as

AgingCattle DiseasesDNA MethylationDNA, MitochondrialAnimalsCattleCell NucleusCpG IslandsEpigenesis, GeneticFemaleDNA, MitochondrialagingDNA methylationepigenetic clockmitochondrianuclear genome

Identifiers

PMID41355493
PMCPMC12688271

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.