ArticleFrontiers in endocrinology2025
High-fat diet-induced obesity accelerates puberty in male rats through SMIM20/phoenixin upregulation.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Controversy exists regarding the relationship between obesity and pubertal onset in boys, and the underlying mechanisms remain unclear. Objective: To establish a high-fat diet (HFD)-induced obesity model in juvenile male Sprague-Dawley (SD) rats, and to investigate the relationship between obesity and pubertal advancement as well as the role of Methods: A HFD (45% fat) was administered to male SD rats to induce obesity, while control rats were maintained on a normal diet (ND) from birth. Body weight and preputial separation were monitored as markers of obesity and pubertal onset. At prepubertal (postnatal day 30, PND30) and early pubertal (PND40) stages, serum, hypothalamus, pituitary, testes, and adipose tissue were collected. RT-qPCR was performed to measure the mRNA expression levels of key genes in the hypothalamic-pituitary-gonadal axis (HPGA), including gonadotropin-releasing hormone ( Results: HFD-fed rats exhibited significantly greater body weight and fat mass than ND-fed rats at both time points. (P<0.001), with earlier preputial separation (P<0.001). Testicular weight and expression of Conclusion: To our knowledge, this study established a novel HFD-induced model of prepubertal obesity and central precocious puberty (CPP) in male rats. The findings suggest that obesity may accelerate pubertal onset, and that Smim20/PNX may participate in regulating pubertal development in males.
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