ReviewThe breast journal2025
Examining the Role of Matrix Metalloproteinase-2 and MicroRNAs Regulation in Breast Cancer.
Review in The breast journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
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Abstract
Matrix metalloproteinase (MMPs) is a class of zinc-dependent enzymes that play an important role in the invasion and metastasis of cancer cells and have different types. MMP-2 is one of the important enzymes of this family. MicroRNAs (miRNAs) are noncoding RNAs that are involved in the regulation of gene expression of many enzymes and factors in the body. Emerging data have highlighted the relationship between MMP-2 and miRNAs. Studies have shown that miRNAs regulate MMP-2 by binding to the 3' untranslated region (3' UTR), which leads to a decrease or increase in MMP-2 expression and its enzymatic activity. For example, decreased expression of miR-106b leads to increased growth and invasion of breast cancer (BC) cells through increased expression of MMP-2. Therefore, understanding the regulatory mechanisms related to MMP-2 and miRNAs will provide new insights into the molecular pathways that drive BC progression and highlight potential therapeutic targets for the management of invasion and metastasis. Hence, in this study, we aimed to elucidate the relationship between MMP-2 and miRNAs in BC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.