ArticleOpen forum infectious diseases2025
Ultrasensitive ELISA for Accurate Detection of
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background: Rapid and accurate diagnostic methods are crucial for curbing the spread of malaria. Antigen-based rapid diagnostic tests are highly valued for their simplicity, but improved sensitivity is needed for more accurate detection. Furthermore, cases of infection with HRP2-deficient parasites are evading testing, meaning patients are not receiving treatment. Methods: We developed an ultrasensitive protein detection system for Results: Our technology detected recombinant PfHRP2 and pLDH at concentrations as low as 0.782 pg/mL and 1.33 pg/mL, respectively. This system detected Conclusions: The detection sensitivity of our system is approximately 10 times greater than that of the latest ultrasensitive antigen detection kits. Our results demonstrate that our developed assay requires no additional processing to separate parasitized erythrocytes from whole blood samples and that the
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