ArticleMaterials today. Bio2025
Lipoic acid-kaempferol hydrogel loaded with Typhaneoside for sutureless wound closure, hemostasis, and healing of diabetic infected wounds.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Multifunctional Hydrogel-Based Scaffolds: Integrating Conductive Nanomaterials for Smart Wound Healing Applications.Gels (Basel, Switzerland) · 2026Review
- An AIE-active polyvinyl alcohol/berberine/hemoadhican smart hydrogel for scarless wound healing with visual pH monitoring.Materials today. Bio · 2026Article
- Advances in Molecular Dynamics Simulations for Hydrogels and Nanocomposite-Reinforced Hydrogels: Multiscale Simulation Strategies and Future Directions.Gels (Basel, Switzerland) · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional hemostatic materials face challenges in adequately addressing the requirements of patients suffering from non-compressible hemorrhage. Furthermore, diabetic infected wounds frequently present a persistent and slow-healing condition. Currently available treatment strategies are unable to fully address non-compressible hemorrhage and promote the healing of diabetic infected wounds. In this study, we prepared a hydrogel named LTK, which is cross-linked by reversible hydrogen bonds and coordination bonds, using lipoic acid(LA)and kaempferol (Ka) as the main raw materials, and loaded it with Typhaneoside(TYP). The LTK-TYP hydrogel can fully diffuse into the irregularities of substrate surfaces and robustly adhere to various substrates. Molecular dynamics simulations further unveiled the atomic details of the formation of the LTK-TYP hydrogel through multi-modal physical interactions. In vitro and in vivo studies demonstrated that the LTK-TYP hydrogel exhibits excellent hemostatic ability, biocompatibility, and wound closure capacity. Moreover, it promotes the healing of diabetic methicillin-resistant
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