Evidence map›Paper›PMID 41356836›Full record

ArticleFrontiers in nutrition2025

Screening for dual-target enzyme inhibitors derived from

Xuanlin Liu, Yang Zhou, Rui Meng, Jingyi Han, Ming Chen, Xiangjie Bo, Sainan Li, Daqian Song, Yuchi Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuanlin LiuCentral Laboratory, Changchun Normal University, Changchun, China.
Yang ZhouCentral Laboratory, Changchun Normal University, Changchun, China.
Rui MengCentral Laboratory, Changchun Normal University, Changchun, China.
Jingyi HanCentral Laboratory, Changchun Normal University, Changchun, China.
Ming ChenCentral Laboratory, Changchun Normal University, Changchun, China.
Xiangjie BoDepartment of Chemistry, Northeast Normal University, Changchun, Jilin, China.
Sainan LiCentral Laboratory, Changchun Normal University, Changchun, China.
Daqian SongCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Changchun, China.
Yuchi ZhangCentral Laboratory, Changchun Normal University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: To efficiently and accurately screen active compounds, receptor-ligand affinity ultrafiltration coupled with enzyme kinetics was used for rapid identification and characterization. Biochemical assays validated the inhibitory activities and mechanisms of the compounds, while molecular docking and molecular dynamics simulations evaluated target binding affinity and stability at the atomic level. An offline two-dimensional chromatographic method was developed to overcome the limitations of conventional countercurrent chromatography, enhancing peak capacity, and separation efficiency. Results: Seven active compounds were successfully isolated and identified from Discussion: This study integrates advanced screening, optimized extraction, and rigorous bioactivity assessment to elucidate the active components of

Indexed as

5-lipoxygenaseacetylcholinesteraseactivity screeningGardenia jasminoides rootoffline 2D-CCC

Identifiers

PMID41356836
PMCPMC12678836

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.