ArticleFrontiers in nutrition2025
Development and validation of an osteoporosis risk prediction model incorporating nighttime eating exposure.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Osteoporosis (OP) is a global bone metabolic disease, and its incidence continues to rise with the intensifying aging of the population. In recent years, chrono-nutrition research has uncovered the significant impact of dietary timing patterns on health, but the relationship between nighttime eating exposure (NEE) and OP remains unclear.This study aimed to confirm through multi-dimensional methodologies that NEE is an independent risk factor for OP. Methods: A clinical cross-sectional study ( Results: NEE was identified as an independent risk factor for OP. In the clinical prediction model, the combination model including NEE (NEE + bone mineral density + age, etc.) demonstrated optimal predictive performance (training set AUC = 0.808). NHANES validation showed a significantly increased OP risk when NEE > 25% (OR = 1.83, 95% CI: 1.27-2.64), with a dose-effect threshold identified (steep risk increase at NEE = 10-25%). Subgroup analysis revealed that the effect size of NEE was significantly higher in individuals with osteopenia (OR = 1.12) compared to those with normal bone mass (OR = 1.06, interaction Discussion: NEE is a novel behavioral risk factor for OP, posing a significant hazard particularly for osteopenic individuals. Its mechanism may be related to circadian rhythm disruption, metabolic dysregulation, and melatonin suppression. This research provides a new direction for precision OP prevention strategies based on "chrono-nutrition."
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