ReviewCureus2025
The Role of Aminothiols as Biomarkers of Oxidative Stress and Clinical Outcomes in Coronary Artery Bypass Grafting (CABG): A Narrative Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Thiol-Disulfide Homeostasis and Erythrocyte Glutathione Balance in ST-Elevation Myocardial Infarction: A Prospective Case-Control Study.Journal of cardiovascular development and disease · 2026Article
- From Exposure to Outcome: Air Pollution-Induced Oxidative Stress as a Determinant of Early and Late Outcomes After Coronary Artery Bypass Grafting.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This narrative review summarizes current evidence on the role of aminothiols as biomarkers of oxidative stress in patients undergoing coronary artery bypass grafting (CABG). CABG is accompanied by profound oxidative and inflammatory stress driven by ischemia-reperfusion injury, cardiopulmonary bypass (CPB), and systemic immune activation. These processes disrupt redox homeostasis and contribute to myocardial injury, arrhythmogenesis, neurocognitive deficits, and impaired graft patency. Aminothiols, including glutathione, cysteine, homocysteine, and cysteinylglycine, are central regulators of intracellular and extracellular redox balance and have emerged as promising biomarkers in this setting. Evidence from clinical studies indicates that elevated preoperative homocysteine predicts perioperative complications, myocardial infarction, atrial fibrillation, and long-term mortality, while perioperative shifts in glutathione and thiol-disulfide ratios reflect oxidative stress dynamics induced by CPB. Interventional trials suggest that antioxidant therapies such as N-acetylcysteine, melatonin, and vitamin C may favorably modulate aminothiol metabolism, although findings remain inconsistent. Despite small sample sizes, methodological heterogeneity, and lack of standardized cut-offs, aminothiols offer mechanistic and prognostic insights. Their integration into multi-biomarker panels, supported by metabolomics and redox proteomics, could enhance perioperative risk stratification and guide personalized redox-modulating strategies in CABG. By synthesizing mechanistic and clinical data, this review highlights the potential of aminothiols for perioperative risk stratification and redox-modulating interventions.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.