ArticleMediators of inflammation2025
Telomere Length and Clear Cell Renal Cell Carcinoma: Unraveling Causal Mechanisms Through Integrative Genetic and Single-Cell Transcriptomic Analysis.
Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Clear cell renal cell carcinoma (ccRCC) presents significant clinical challenges. This study investigates the causal relationship between telomere length (TL) and ccRCC risk using a comprehensive multicohort genetic approach. Methods: We conducted a rigorous two-sample Mendelian randomization (MR) analysis using independent discovery (UK Biobank, Results: In the discovery cohort, inverse variance weighted (IVW) MR analysis revealed a significant positive association between TL and ccRCC risk (odds ratio [OR]: 1.604, 95% confidence interval [CI]: 1.358-1.895, Conclusion: Our comprehensive multiomics study provides robust evidence of a causal relationship between TL and ccRCC risk. By integrating genetic epidemiology and single-cell transcriptomics, we unveil novel molecular mechanisms underlying ccRCC pathogenesis and identify potential therapeutic targets.
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