Evidence mapPaperPMID 41357321Full record

ArticleJournal of diabetes research2025

The Association of Lipoic Acid Synthase (

Ziyi Feng, Ting Liu, Peng Gao, Yongwei Jiang, Meimei Zhao, Yi Liu, Haoyan Zhu, Mo Li, Nan Li, Xiaomu Kong and 1 more

Abstract read
In one paragraph

Article in Journal of diabetes research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ziyi FengChina-Japan Friendship Institute of Clinical Medicine Research, China-Japan Friendship Hospital, Beijing, China.ORCID https://orcid.org/0009-0000-8244-7524
Ting LiuChina-Japan Friendship Institute of Clinical Medicine Research, China-Japan Friendship Hospital, Beijing, China.
Peng GaoDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-7096-2710
Yongwei JiangDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-4974-0283
Meimei ZhaoDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-6031-5544
Yi LiuDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-5743-0621
Haoyan ZhuDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
Mo LiDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
Nan LiDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
Xiaomu KongDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-5920-4759
Liang MaDepartment of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.ORCID https://orcid.org/0000-0003-3226-4150

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD). The dysregulation of lipoic acid synthase ( Methods: A cohort of 308 patients, comprising 156 patients with Type 2 diabetes mellitus (T2DM) with DKD (DKD group) and 152 with T2DM alone (T2DM group), were involved in the present study. A methylation-sensitive restriction endonuclease (MSRE)-qPCR approach combined with three enzymes (HpaII, AciI, and Hin6I) was developed to examine methylation patterns of the promoter region and exon 1 of Results: We successfully identified the methylation sites that can be recognized and digested by HpaII, AciI, and Hin6I, in the CpG islands of Conclusion: The findings indicate that

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesDNA MethylationSulfurtransferasesAdultAgedCpG IslandsFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPromoter Regions, Geneticlipoic acid synthaseSulfurtransferasesdiabetic kidney diseaseDNA methylationLIASoxidative stress

Identifiers

PMID41357321
PMCPMC12680467

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.