Association between serum total cholesterol levels and Crohn's clinical disease severity: a retrospective cross-sectional study.

Jinchun Ni, Yunna Tang, Fangyuan Zhou, Yiqun Hu, Lupeng Liu, Mingcheng Huang, Hui Ouyang, Chenxi Xie

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Jinchun Ni *Department of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, School of Medicine, Zhongshan Hospital Xiamen University, Xiamen University, Xiamen, Fujian, China.

Yunna Tang *Department of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, School of Medicine, Zhongshan Hospital Xiamen University, Xiamen University, Xiamen, Fujian, China.

Fangyuan Zhou *Department of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, School of Medicine, Zhongshan Hospital Xiamen University, Xiamen University, Xiamen, Fujian, China.

Yiqun HuDepartment of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, School of Medicine, Zhongshan Hospital Xiamen University, Xiamen University, Xiamen, Fujian, China.

Lupeng LiuDepartment of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, School of Medicine, Zhongshan Hospital Xiamen University, Xiamen University, Xiamen, Fujian, China.

Mingcheng HuangDepartment of Nephrology, Center of Kidney and Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.

Hui OuyangDepartment of Digestive Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.

Chenxi XieDepartment of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, School of Medicine, Zhongshan Hospital Xiamen University, Xiamen University, Xiamen, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This retrospective cross-sectional study aimed to investigate the relationship between serum total cholesterol (TC) levels and the clinical activity of Crohn's disease (CD). Methods: One hundred and four patients with Crohn's disease (CD) and twenty healthy volunteers were included in the analysis. Serum uric acid (SUA) levels and indicators related to lipid metabolism were measured within 1 week before undergoing endoscopic and CT enterography (CTE) examinations. Patients were divided into groups based on their Crohn's Disease Activity Index (CDAI) scores. Results: Patients were categorized into mild and moderate groups, with no patients meeting the criteria for severe CD. The serum uric acid (SUA) and triglyceride (TG) levels were similar between CD patients and the control group ( Conclusion: TC may serve as a potential supplementary marker for clinical disease activity in CD, but further research, including longitudinal studies, is needed to confirm its reliability.

Indexed as

CDAI scoresclinical disease activityCrohn’s diseaseserum total cholesterolsupplementary marker

Identifiers

PMID41357478

DOI10.3389/fmed.2025.1708838

PMCPMC12678240

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.