ArticleJournal of inflammation research2025
Association of the Cumulative Inflammatory Index and Long-Term Mortality in Stroke-Associated Pneumonia.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Prognostic Value of the Cumulative Inflammatory Index (IIC) in Patients with Non-ST-Segment Elevation Myocardial Infarction.Biomedicines · 2026Article
- Stroke-Associated Pneumonia and Impaired Functional Recovery After Stroke: The Role of Nutritional-Inflammatory Factors.Advances in respiratory medicine · 2026Article
- Hematological Predictors of Impaired Postpartum Uterine Involution in Thrombophilia: A Multivariate Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Comment on "Association of the Cumulative Inflammatory Index and Long-Term Mortality in Stroke-Associated Pneumonia" [Letter].Journal of inflammation research · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Stroke-associated pneumonia (SAP) represents a common complication that increases the mortality risk in individuals who have experienced a stroke. We aimed to explore the relationship between the cumulative inflammatory index (IIC) and long-term mortality in patients with SAP. Methods: This study sourced participants with SAP from the Nanjing Stroke Registry Program. The IIC was computed using the formula: (mean corpuscular volume × red cell distribution width × neutrophils) divided by (lymphocytes × 1000). To gauge the diagnostic utility of inflammatory markers, time-dependent receiver operating characteristic curves were plotted. Furthermore, to elucidate the connection between IIC and long-term mortality, survival analysis was conducted via Cox proportional hazard regression models. Results: The analysis enrolled a total of 557 SAP patients, with a median age of 66 years and 391 males accounting for 70.2% of the cohort. The predictive accuracy of the IIC for mortality was 0.697 (95% confidence interval [CI]: 0.637-0.757). In Cox proportional hazard regression models, the IIC was significantly related to mortality (continuous: hazard ratio [HR]: 1.04; 95% CI: 1.02-1.06; Conclusion: This research revealed that elevated IIC levels were linked to a heightened long-term mortality risk among individuals with SAP. IIC may emerge as a feasible and robust biomarker for mortality prediction in SAP patients.
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