ArticleFrontiers in pharmacology2025
Anti-ulcer activity of green synthesized selenium nanoparticles using
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Objectives: Selenium nanoparticles (SeNPs) have gained importance due to their potential biological properties. The present work is the first study to investigate the protective effect of selenium nanoparticles (SeNPs) synthesized using Methods: The formation of SeNPs was confirmed by Ultraviolet-visible (UV), Fourier Transform Infrared Spectroscopy (IR), Thermal-gravimetric analysis (TGA-DTA coupled system), X-ray diffraction analysis (XRD) and scanning electron microscope (SEM) analysis. Animals were classified into 4 distinct groups. Group 1, serving as controls; group 2, serving as ulcer-group where rats received a single oral dosage of 96% ethanol (5 mL/Kg BW). Rats in Group 3 were given orally 0.5 mg/kg BW of SeNPs 1 hour before ethanol-induced gastric ulcer. Group 4 received SeNPs only (0.5 mg/kg BW) by intragastric way and served as a positive control. Results: Green synthesis was confirmed via UV-Vis spectroscopy (230 nm peak), FTIR revealed functional groups (O-H, C=O, Se-O or Se-Se). XRD pattern shows an average crystallite sizes of nanoparticles were around 26 (4) and 268 (4) nm for β-SeO2 and g-SeO2 forms, respectively. SEM examination indicated that SeNPs have a predominantly spherical to sub-spherical morphology. TG-DTA analysis demonstrates the good thermal stability of selenium nanoparticles, evidenced by initial moisture loss, controlled degradation of organic stabilizers and the formation of a stable inorganic selenium core. SeNPs' protective effects were assessed by evaluating the ulcer index, conducting histological analysis, measuring oxidative stress markers and antioxidant defenses, as well as examining key factors involved in gastric mucosal protection. Our results demonstrated that SeNPs reduced malondialdehyde (MDA), and advanced oxidation protein product (AOPP) levels, nitric oxide (NO) levels in stomach of ethanol-induced gastric ulcer, as well as the activities of Catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD); while glutathione (GSH) and non-protein thiols (NPSH) levels were restored reaching control values. Moreover, the gastric healing effect of SeNPs pretreatment was associated with an improvement in hematological parameters and a reduction in CRP levels. Conclusion: These findings underscore the potential of SeNPs to enhance the antioxidant defense system of gastric mucosal cells and prevent ethanol-induced gastric damage in rats.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.